Comparison of two different regimens of combined interferon-α2a and lamivudine therapy in children with chronic hepatitis B infection

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dc.contributor.authorKansu A.
dc.contributor.authorDoǧanci T.
dc.contributor.authorAkman S.A.
dc.contributor.authorArtan R.
dc.contributor.authorKuyucu N.
dc.contributor.authorKalayci A.G.
dc.contributor.authorDikici B.
dc.contributor.authorDalgiç B.
dc.contributor.authorSelimoǧlu A.
dc.contributor.authorKasirga E.
dc.contributor.authorÖzkan T.B.
dc.contributor.authorKuloǧlu Z.
dc.contributor.authorAydoǧdu S.
dc.contributor.authorBoşnak M.
dc.contributor.authorErtekin V.
dc.contributor.authorTanir G.
dc.contributor.authorHaspolat K.
dc.contributor.authorGirgin N.
dc.contributor.authorYaǧci R.V.
dc.date.accessioned2024-07-22T08:23:22Z
dc.date.available2024-07-22T08:23:22Z
dc.date.issued2006
dc.description.abstractAim: To evaluate the efficacy of two regimens of combined interferon-α2a (IFN-α2a) and lamivudine (3TC) therapy in childhood chronic hepatitis B. Methods: A total of 177 patients received IFN-α2a, 9 million units (MU)/m2 for 6 months. In group I (112 patients, 8.7±3.5 years), 3TC (4 mg/kg/day, max 100 mg) was started simultaneously with IFN-α2a, in group II (65 patients, 9.6±3.8 years) 3TC was started 2 months prior to IFN-α2a. 3TC was continued for 6 months after antiHBe seroconversion or stopped at 24 months in non-responders. Results: Baseline alanine aminotransferase (ALT) was 134.2±34.1 and 147.0±45.3; histological activity index (HAI) was 7.4±2.7 and 7.1±2.3; and HBV DNA levels were above 2,000 pg/ml in 76% and 66% of patients in groups I and II, respectively (P>0.005). Complete response was 55.3% and 27.6% in groups I and II, respectively (P<0.01). AntiHBe seroconversion was higher and earlier, and HBV DNA clearance was earlier in group I (P<0.05). HBsAg clearance was 12.5% and 4.6% and antiHBs seroconversion was 9.8% and 6.2% in groups I and II, respectively (P>0.05). Breakthrough occurred in 17.9% and 24.6%; breakthrough times were 15.9±4.6 and 14.1±5.1 months; and relapse rates were 6.8% and none in groups I and II, respectively (P>0.05, P>0.05, P>0.05). Responders had higher HAI (HAI>6) and higher pre-treatment ALT than non-responders. Conclusion: Simultaneous 3TC+IFN-α2a yields a higher response and earlier antiHBe seroconversion and viral clearance than consecutive combined therapy. Relapse rate is low. Predictors of response are high basal ALT and high HAI scores. 3TC can be administered for 24 months without any side effect and breakthrough rate is comparable with previous studies. © 2006 International Medical Press.
dc.identifier.issn13596535
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19501
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAlanine Transaminase
dc.subjectAntiviral Agents
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDNA, Viral
dc.subjectDrug Administration Schedule
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectHepatitis B e Antigens
dc.subjectHepatitis B, Chronic
dc.subjectHumans
dc.subjectInterferon Alfa-2a
dc.subjectLamivudine
dc.subjectMale
dc.subjectSex Hormone-Binding Globulin
dc.subjectViral Load
dc.subjectalanine aminotransferase
dc.subjectalpha2a interferon
dc.subjecthepatitis B surface antigen
dc.subjectlamivudine
dc.subjectvirus DNA
dc.subjectadolescent
dc.subjectadult
dc.subjectarticle
dc.subjectchildhood disease
dc.subjectchronic hepatitis
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjectflu like syndrome
dc.subjecthepatitis B
dc.subjectHepatitis B virus
dc.subjecthuman
dc.subjectleukopenia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectprediction
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectrelapse
dc.subjectseroconversion
dc.subjectthrombocytopenia
dc.subjecttreatment response
dc.titleComparison of two different regimens of combined interferon-α2a and lamivudine therapy in children with chronic hepatitis B infection
dc.typeArticle

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