The effects of gender and menopause on serum lidocaine levels in smokers

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dc.contributor.authorOztekin S.
dc.contributor.authorMavioglu O.
dc.contributor.authorElar Z.
dc.contributor.authorGuven H.
dc.contributor.authorKalkan Ş.
dc.contributor.authorGurpinar T.
dc.date.accessioned2024-07-22T08:24:07Z
dc.date.available2024-07-22T08:24:07Z
dc.date.issued2005
dc.description.abstractIt has been established that human cytochrome P450 (CYP) enzymatic activity is affected by gender, or by hormonal factors such as the menopause in women. Gender differences have a more pronounced effect on cytochrome (CYP) 3A4 isoenzyme activity, whereas cytochrome (CYP) 1A2 isoenzyme activity is mainly induced by chronic smoking. Lidocaine is frequently used in the treatment of hemodynamic changes following laryngoscopy and tracheal intubation during general anesthesia, and is metabolized by CYP3A4 and CYP1A2 isoenzymes in the liver. The aim of this study was investigate the effects of gender and menopause on serum lidocaine levels in smokers under general anesthesia. Six men, six premenopausal women and six postmenopausal women were enrolled in the study and received i.v. lidocaine (1 mg/kg) 1 minute before they underwent general anesthesia. Serum lidocaine concentrations were measured using the EMIT® method at 1, 5, 10, 20, 40 and 60 minutes post-administration. Statistical analyses were performed using the Mann-Whitney U-test. No statistically significant differences were found regarding the area under curve (AUC (0-60) μg/mL/min), elimination half-life (t1/2 [min]) of lidocaine and in the measured levels of serum lidocaine at any time point between the study groups (p>0.05). These results suggest that gender and menopause may have no significant effect on serum lidocaine levels in smokers.
dc.identifier.DOI-ID10.1007/BF03190625
dc.identifier.issn03787966
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19844
dc.language.isoEnglish
dc.publisherEditions Medecine et Hygiene
dc.subjectcytochrome P450
dc.subjectcytochrome P450 1A2
dc.subjectcytochrome P450 3A4
dc.subjectisoenzyme
dc.subjectlidocaine
dc.subjectadult
dc.subjectarea under the curve
dc.subjectarticle
dc.subjectcigarette smoking
dc.subjectclinical article
dc.subjectdrug blood level
dc.subjectdrug effect
dc.subjectdrug half life
dc.subjectendotracheal intubation
dc.subjectenzyme activity
dc.subjectfemale
dc.subjecthormonal regulation
dc.subjecthuman
dc.subjectintrinsic sympathomimetic activity
dc.subjectliver metabolism
dc.subjectmale
dc.subjectmenopause
dc.subjectmenstrual cycle
dc.subjectsex difference
dc.titleThe effects of gender and menopause on serum lidocaine levels in smokers
dc.typeArticle

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