The effect of sodium iodide symporter protein on ablation success in patients with differentiated thyroid cancer
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2022
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Abstract
Objective: This study aimed to investigate immunohistochemical staining of sodium iodide symporter (NIS) and its effect on response to I-131 therapy in differentiated thyroid carcinoma patients. Methods: We evaluated NIS expression, the intracellular distribution of NIS, iodine-131 uptake in residual tissues on post-ablation I-131 whole body scan, and the ablation status after 100 mCi I-131 therapy. We also investigated NIS expression and localization in tumoral paraffin-embedded tissues. Results: In this retrospective study, 35 patients (mean age 44.17 ± 12.9 years, 27 female, 8 male) were studied. Twenty-one of these patients responded to radioiodine therapy, and 14 did not. NIS expression and iodine-131 uptake in residual tissues post-ablation I-131 whole body scan were not statistically significant. When we compared the patients who responded to radioiodine therapy and the poor responder group, NIS expression and iodine-131 uptake in residual tissues did not demonstrate statistically significant difference [(p = 0.308) (p = 0.985) respectively]. 47.6% of the patients in the successful ablation group and 85.7% in the unsuccessful ablation group had intracellular NIS immunostaining. The difference was not statistically significant (p = 0.139). 52.4% of the patients in the successful ablation group and 7% in the unsuccessful ablation group had NIS immunostaining at the basolateral membrane. The difference was statistically significant (p < 0.05). Conclusions: In conclusion, we did not find any significant difference between successful and unsuccessful ablation groups in terms of NIS expression; however, we concluded that the intracellular (cytoplasmic) localization of NIS is one of the leading causes of ablation failure regardless of NIS expression in DTC patients. © 2022, The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine.
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Adenocarcinoma , Adult , Female , Humans , Iodine Radioisotopes , Male , Middle Aged , Retrospective Studies , Symporters , Thyroid Neoplasms , antibody , buffer , distilled water , hematoxylin , iodine , iodine 131 , levothyroxine , paraffin , radioactive iodine , sodium iodide symporter , thyrotropin , cotransporter , Iodine-131 , radioactive iodine , sodium iodide symporter , adult , aged , Article , basolateral membrane , cancer patient , cellular distribution , clinical article , controlled study , differentiated thyroid cancer , distant metastasis , drug therapy , female , follicular carcinoma , human , human tissue , immunohistochemistry , lack of drug effect , male , metastasis , protein expression , protein function , retrospective study , thyroid cancer , thyroid papillary carcinoma , treatment failure , whole body scintiscanning , young adult , adenocarcinoma , metabolism , middle aged , thyroid tumor