Assessment of in vitro antitumoral and antimicrobial activities of marine algae harvested from the eastern Mediterranean sea
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Date
2010
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Abstract
Antitumoral activities of five algal extracts obtained from the marine algae Scytosiphon lomentaria, Padina pavonica, Cystoseira mediterranea (Phaeophyceae), Hypnea musciformis and Spyridia filamentosa (Rhodophyta) were assessed against the human breast adenocarcinoma cell line MCF-7 and the human prostate carcinoma epithelium like cell lines DU 145, LNCaP, PC3 using the cytotoxic assay, in vitro. The crude extract of S. filamentosa showed strong cytotoxic activity against the DU-145 cell line, and it showed less than 10% cell viability after treatment. Antimicrobial activities of the crude extracts of algae (with the exception of H. musciformis) were also tested by disc diffusion assay against three Gram positive and five Gram negative bacterial strains and against the yeast pathogen Candida albicans. Among the extraxts, S. lomentaria extract (prepared with methanol) inhibited highly Gram negative bacterium Salmonella typhimurium growth while C. albicans growth was only inhibited by C. mediterrranea extract. © 2010 Academic Journals.
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Keywords
algae , Bacteria (microorganisms) , Candida albicans , Cystoseira mediterranea , Hypnea musciformis , Negibacteria , Padina pavonia , Phaeophyceae , Posibacteria , Rhodophyta , Salmonella typhimurium , Scytosiphon lomentaria , Spyridia filamentosa , algal extract , antiinfective agent , antineoplastic agent , Cystoseira mediterranea extract , Hypnea musciformis extract , methanol , Padina pavonica extract , Scytosiphon lomentaria extract , Spyridia filamentosa extract , unclassified drug , alga , antimicrobial activity , antineoplastic activity , article , bacterial growth , bacterial strain , breast adenocarcinoma , cancer cell culture , Candida albicans , cell strain MCF 7 , cell viability , controlled study , Cystoseira mediterranea , cytotoxicity , disk diffusion , drug isolation , fungus growth , Gram negative bacterium , Gram positive bacterium , human , human cell , Hypnea musciformis , in vitro study , marine species , nonhuman , Padina pavonica , prostate carcinoma , Salmonella typhimurium , Scytosiphon lomentaria , seaweed , Spyridia filamentosa