Serum lipids and apolipoproteins in patients with psoriasis

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dc.contributor.authorUyanik B.S.
dc.contributor.authorAri Z.
dc.contributor.authorOnur E.
dc.contributor.authorGündüz K.
dc.contributor.authorTanülkü S.
dc.contributor.authorDurkan K.
dc.date.accessioned2024-07-22T08:25:10Z
dc.date.available2024-07-22T08:25:10Z
dc.date.issued2002
dc.description.abstractPsoriasis is characterized by defects in the normal cycle of epidermal development that lead to epidermal hyperproliferation, altered maturation of skin cells, vascular changes and inflammation. Also, psoriasis has been associated with an abnormal plasma lipid metabolism. Changes in plasma lipid and lipoprotein composition in patients with psoriasis may be the reason for the increased risk of atherosclerosis in these patients. We determined serum concentrations of lipids, lipoproteins and apolipoprotein A1 and B (apo A1 and apo B) in 72 patients with psoriasis and 30 age-matched controls. Serum lipoprotein (a) (Lp(a)), apo A1 and apo B were measured by immunoprecipitation assays, and the lipids and other biochemical parameters by enzymatic methods. Serum Lp(a) and triglyceride (TG) were significantly higher in patients with psoriasis than in healthy control subjects (p<0.01 for both). Apo B was also found to be higher in the patient group, but the difference was not significant. The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and apo A1 did not differ significantly from those of the controls. These observations imply that serum Lp(a) and TG concentrations may play a role as risk factors for atherosclerotic disease in patients with psoriasis.
dc.identifier.DOI-ID10.1515/CCLM.2002.013
dc.identifier.issn14346621
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20280
dc.language.isoEnglish
dc.subjectAdult
dc.subjectApolipoproteins
dc.subjectCase-Control Studies
dc.subjectCholesterol
dc.subjectFemale
dc.subjectHumans
dc.subjectLipids
dc.subjectLipoproteins
dc.subjectMale
dc.subjectPsoriasis
dc.subjectapolipoprotein
dc.subjectapolipoprotein A1
dc.subjectapolipoprotein B
dc.subjectcholesterol
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlipid
dc.subjectlipoprotein
dc.subjectlipoprotein A
dc.subjectlow density lipoprotein cholesterol
dc.subjecttriacylglycerol
dc.subjectadult
dc.subjectarticle
dc.subjectatherosclerosis
dc.subjectcell maturation
dc.subjectcell proliferation
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectenzyme chemistry
dc.subjectepidermis
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunoprecipitation
dc.subjectinflammation
dc.subjectlipid blood level
dc.subjectlipid metabolism
dc.subjectmale
dc.subjectpriority journal
dc.subjectpsoriasis
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectskin cell
dc.subjecttriacylglycerol blood level
dc.subjectvascular disease
dc.titleSerum lipids and apolipoproteins in patients with psoriasis
dc.typeArticle

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