T Cell Subpopulations and IL-2R in Vitiligo

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dc.contributor.authorGunduz K.
dc.contributor.authorOzturk G.
dc.contributor.authorTerzioglu E.
dc.contributor.authorSebik F.
dc.date.accessioned2024-07-22T08:24:30Z
dc.date.available2024-07-22T08:24:30Z
dc.date.issued2004
dc.description.abstractImmunological alterations have been implicated in the etiopathogenesis of vitiligo. The aim of this study was to determine peripheral lymphocyte subpopulations and interleukin-2 receptor (IL-2R) in patients with vitiligo. Forty-five vitiligo patients (24 female, 21 male) and 34 healthy controls (11 female, 23 male) were included into the study. Eight (17.8%) of the patients had the segmental type, and 37 (82.2%) had generalized vitiligo. The disease was active in 25 (55.6%) patients; the other 20 (44.4%) patients had static vitiligo. Flow cytometry was used to determine the percentages of total T-lymphocytes, B-lymphocytes, helper/inducer T cells, suppressor/cytotoxic T cells, natural killer (NK) cells, activated T cells and interleukin-2 receptor (IL-2R) with the use of CD3, CD19, CD4, CD8, CD16, HLA-DR and CD25 monoclonal antibodies, respectively. The mean value of helper T cells showed a significant difference (p=0.01) between the two groups with the value being 32.5% in patients and 38.1% in control subjects. CD4/CD8 was significantly lower in vitiligo patients (p=0.04). There was also a statistically significant difference in the mean percentage of activated T cells between vitiligo patients and control subjects (4.7 and 8.1, respectively; p=0.001). No statistically significant differences were found when the values were compared between segmental and generalized vitiligo patients, or between active and static cases. In conclusion, T helper/inducer cells, CD4/CD8 ratio and activated (HLA-DR+) T cells are decreased in vitiligo patients, suggesting a role for changes in cellular immunity.
dc.identifier.DOI-ID10.1111/j.1346-8138.2004.tb00514.x
dc.identifier.issn03852407
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19990
dc.language.isoEnglish
dc.publisherJapanese Dermatological Association
dc.subjectCD16 antigen
dc.subjectCD19 antigen
dc.subjectCD3 antigen
dc.subjectCD4 antigen
dc.subjectCD8 antigen
dc.subjectHLA DR antigen
dc.subjectinterleukin 2 receptor
dc.subjectmonoclonal antibody
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectB lymphocyte
dc.subjectcellular immunity
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcytotoxic T lymphocyte
dc.subjectflow cytometry
dc.subjecthelper cell
dc.subjecthuman
dc.subjectmale
dc.subjectnatural killer cell
dc.subjectT lymphocyte subpopulation
dc.subjectvitiligo
dc.titleT Cell Subpopulations and IL-2R in Vitiligo
dc.typeArticle

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