Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus
| dc.contributor.author | Gur, EB | |
| dc.contributor.author | Karadeniz, M | |
| dc.contributor.author | Genc, M | |
| dc.contributor.author | Eskicioglu, F | |
| dc.contributor.author | Yalcin, M | |
| dc.contributor.author | Hepyilmaz, I | |
| dc.contributor.author | Guclu, S | |
| dc.date.accessioned | 2025-04-10T10:31:36Z | |
| dc.date.available | 2025-04-10T10:31:36Z | |
| dc.description.abstract | Objective: To investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies. Subjects and methods: This study included 200 pregnant women. 25-hydroxyvitamin D-3 (25(OH)D-3) and MPV values were monitored between pregnant women with GDM and normal glucose metabolism. Correlation between 25(OH)D-3 and MPV was calculated both in GDM and healthy pregnancies. Both 25(OH)D-3 level in different MPV percentile (<= 50, 50-75, 75-90, >= 90 percentile) and MPV value in different 25(OH)D-3 level (<= 10, 10-20, >= 20 ng/mL) were calculated. Results: Low 25(OH)D-3 level and high MPV were observed both in GDM group (p = 0.007, p = 0.06, respectively) and in glucose metabolism disorders (GMD) group (p = 0.03, p = 0.04, respectively). There was no significant relationship between 25(OH)D-3 and MPV in healthy pregnancies. Whereas, it is observed that there is a negative, but statistically insignificant correlation between MPV and 25(OH)D-3 pregnant women with GMD (r = 0.1, r = -0.7, respectively). MPV values had significantly higher in vitamin D deficient group than pregnant women with normal 25(OH)D-3 level in GMD group (p = 0.04). The optimal 25(OH)D-3 cut off point for predicting future cardiovascular risk was 10.4 ng/mL (area under curve (AUC) = 0.58). Conclusions: Vitamin D deficiency may contribute to an increased risk for future cardiovascular diseases and a risk of thrombotic complications in pregnant women with GDM. | |
| dc.identifier.e-issn | 2359-4292 | |
| dc.identifier.issn | 2359-3997 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/38077 | |
| dc.language.iso | English | |
| dc.title | Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus | |
| dc.type | Article |