Toll-like receptor 2 expression and peripheral blood CD4+/CD8+ T cell ratio in COPD

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dc.contributor.authorUlutaş G.Ş.
dc.contributor.authorAlpaydin A.Ö.
dc.contributor.authorTaneli F.
dc.contributor.authorÇetinkaya C.
dc.contributor.authorUlman C.
dc.contributor.authorGüvenç Y.
dc.contributor.authorHorasan G.D.
dc.contributor.authorCoşkun A.Ş.
dc.date.accessioned2024-07-22T08:17:05Z
dc.date.available2024-07-22T08:17:05Z
dc.date.issued2014
dc.description.abstractOBJECTIVES: We aimed to evaluate toll-like receptor 2 (TLR-2) expression on monocytes and peripheral blood CD4+/CD8+ T cell ratio, as well as the relationship of these cells with pulmonary functions in chronic obstructive pulmonary disease (COPD) patients. MATERIAL AND METHODS: Forty COPD patients and 40 healthy volunteers were included. Participants were analysed in four groups according to their smoking status. Peripheral blood CD4+ and CD8+ T cells and monocyte TLR-2 expression were measured by flow cytometry in the whole study population. RESULTS: No significant difference was observed in TLR-2 expression, number of CD4+ and CD8+ T cells, and CD4+/CD8+ T cell ratio between the study groups. CD4+/CD8+ T cell ratio and FEV1/FVC were found to have a mild positive correlation (r=0.295, p=0.022). A mild negative correlation was observed between smoking intensity and CD4+/CD8+ T cell ratio (r=-0.274, p=0.034). CONCLUSION: We demonstrated a mild correlation between pulmonary functions and peripheral blood CD4+/CD8+ T cell ratio. However, we did not find a significant difference in TLR-2 expression of CD14+ monocytes in patients with airway obstruction. © 2014 by Turkish Thoracic Society.
dc.identifier.DOI-ID10.5152/ttd.2014.3842
dc.identifier.issn13027808
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16963
dc.language.isoEnglish
dc.publisherAVES Ibrahim Kara
dc.subjecttoll like receptor 2
dc.subjectadult
dc.subjectarticle
dc.subjectCD4 CD8 ratio
dc.subjectchronic obstructive lung disease
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectflow cytometry
dc.subjectforced expiratory volume
dc.subjectforced vital capacity
dc.subjecthemolysis
dc.subjecthuman
dc.subjectlung function
dc.subjectlung function test
dc.subjectmale
dc.subjectmonocyte
dc.subjectsmoking
dc.titleToll-like receptor 2 expression and peripheral blood CD4+/CD8+ T cell ratio in COPD
dc.typeArticle

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