The association of HLA-G and immune markers in recurrent miscarriages

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dc.contributor.authorEskicioğlu F.
dc.contributor.authorÖzdemir A.T.
dc.contributor.authorÖzdemir R.B.
dc.contributor.authorTuran G.A.
dc.contributor.authorAkan Z.
dc.contributor.authorHasdemir S.P.
dc.date.accessioned2024-07-22T08:11:42Z
dc.date.available2024-07-22T08:11:42Z
dc.date.issued2016
dc.description.abstractObjective: To determine role of human leukocyte antigen (HLA)-G, CD8, CD16, CD56, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α for recurrent miscarriages in feto–maternal interface. Method: Chorion and decidua samples were obtained from 11 women with unwanted pregnancies (healthy pregnancy, HP) and 10 women with missed abortion diagnosis after at least two pregnancy losses (recurrent miscarriage, RM). In addition, endometrial tissues were obtained from 10 non-pregnant women (NonP). The expressions of markers were evaluated using the Western blot analysis. The values obtained between different groups were compared. Results: The highest protein expression of CD56 was found in the HP compared to NonP and RM. Meanwhile, the lowest protein expression of CD16 was observed in the NonP compared to HP and RM. The HLA-G expression exhibited the highest level in HP; however, there was no statistically significant difference between groups. CD8 and IFNγ expressions were lowest in the NonP group; however, TNF-α was highest in the RM group. Conclusions: The CD56 expression of uterine NK cells may be an indicator of a HP. However, not statistically significant, the increased expression of CD16, CD8, and also significantly increased expression of TNF may be associated with the predominant cytotoxic activity in the maternal immune system in patients with RM. Although there was no change in the expression of HLA-G, this finding may mean that the maternal immune system is unresponsive to HLA-G-mediated immunosuppressive signals originating from the fetus in these cases. © 2015 Taylor & Francis.
dc.identifier.DOI-ID10.3109/14767058.2015.1114085
dc.identifier.issn14767058
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15755
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd
dc.subjectAbortion, Habitual
dc.subjectAdult
dc.subjectAntigens, CD56
dc.subjectBiomarkers
dc.subjectBlotting, Western
dc.subjectDecidua
dc.subjectFemale
dc.subjectHLA-G Antigens
dc.subjectHumans
dc.subjectInterferon-gamma
dc.subjectKiller Cells, Natural
dc.subjectPregnancy
dc.subjectProspective Studies
dc.subjectTumor Necrosis Factor-alpha
dc.subjectYoung Adult
dc.subjectCD16 antigen
dc.subjectCD56 antigen
dc.subjectCD8 antigen
dc.subjectgamma interferon
dc.subjectHLA G antigen
dc.subjecttumor necrosis factor alpha
dc.subjectbiological marker
dc.subjectCD56 antigen
dc.subjectgamma interferon
dc.subjectHLA G antigen
dc.subjecttumor necrosis factor
dc.subjectadult
dc.subjectArticle
dc.subjectchorion
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectdecidua
dc.subjectdisease association
dc.subjectdisease marker
dc.subjectendometrium
dc.subjectfemale
dc.subjectfetus
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmissed abortion
dc.subjectnatural killer cell
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectprotein expression
dc.subjectrecurrent disease
dc.subjectspontaneous abortion
dc.subjectunwanted pregnancy
dc.subjectuterus
dc.subjectWestern blotting
dc.subjectchemistry
dc.subjectmetabolism
dc.subjectpregnancy
dc.subjectrecurrent abortion
dc.subjectyoung adult
dc.titleThe association of HLA-G and immune markers in recurrent miscarriages
dc.typeArticle

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