The long-term effect of mesh bioprosthesis in inguinal hernia repair on testicular nitric oxide metabolism and apoptosis in rat testis
| dc.contributor.author | Taneli, F | |
| dc.contributor.author | Aydede, H | |
| dc.contributor.author | Vatansever, S | |
| dc.contributor.author | Ulman, C | |
| dc.contributor.author | Ari, Z | |
| dc.contributor.author | Uyanik, BS | |
| dc.date.accessioned | 2025-04-10T10:29:35Z | |
| dc.date.available | 2025-04-10T10:29:35Z | |
| dc.description.abstract | Polypropylene mesh is the most widely used material in inguinal hernia repair. Although polypropylene mesh is known as an inert material, it is experimentally proven that mesh generates a chronic inflammatory tissue reaction. The aim of the present study was to investigate the long-term effects of polypropylene mesh material used in inguinal hernia operations on testicular function, testicular nitric oxide (NO) metabolism and germ cell-specific apoptosis in rats. The study comprised 40 male rats that were randomly allocated into two groups. In group 1, the left spermatic cord was elevated and a 0.5 x 1 cm polypropylene mesh was placed behind the left inguinal spermatic cord and group 2 consisted of the sham-operated controls. Blood samples were taken at 6 months preoperatively and postoperatively after to assess luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels for hormonal evaluation. Testicular NO was evaluated by the Griess method, apoptosis by a TUNEL method and inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) expressions by immunohistochemical staining. Mild (+) eNOS expression was observed in all specimens. Mild (+) iNOS expression was only detected in ipsilateral testis of the mesh-implanted study group. Apoptotic cells were not detected in any samples. We are of the opinion that long-term polypropylene mesh implantation has no effect on testicular hormonal function and only a limited effect on nitric oxide levels and this effect is not sufficient to cause apoptosis in testis that could lead to infertility. It seems that mesh implantation is a reliable method in inguinal hernia repair; however, further work is required by more sensitive methods to fully elucidate the potential testicular damage. Copyright (c) 2004 John Wiley & Sons, Ltd. | |
| dc.identifier.e-issn | 1099-0844 | |
| dc.identifier.issn | 0263-6484 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/36268 | |
| dc.language.iso | English | |
| dc.title | The long-term effect of mesh bioprosthesis in inguinal hernia repair on testicular nitric oxide metabolism and apoptosis in rat testis | |
| dc.type | Article |