A comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjects

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dc.contributor.authorEskiizmir G.
dc.contributor.authorHirçin Z.
dc.contributor.authorÖzyurt B.
dc.contributor.authorÜnlü H.
dc.date.accessioned2024-07-22T08:20:35Z
dc.date.available2024-07-22T08:20:35Z
dc.date.issued2011
dc.description.abstractBackground: Oxymetazoline and xylometazoline are locally effective and direct acting drugs that relieve nasal congestion. The aim of this study was to objectively determine and compare the decongestive effects of oxymetazoline and xylometazoline in healthy subjects. Methods: The study population comprised thirty healthy adults. All subjects underwent active anterior rhinomanometry (AARhm) and acoustic rhinometry (AR) tests following the application of oxymetazoline, xylometazoline, or placebo (physiological saline). The change in nasal resistance, nasal airflow, and different cross-sectional areas (CSAs) of the nasal cavity in the subjects were examined for each solution separately. The measurements were obtained over a 1-h period (baseline and 1, 15, 30, and 60 min post-dosing). All results were analyzed using the Kruskal-Wallis test and the Mann-Whitney U test. Results: A total of 6,300 measurements of AARhm and AR were obtained. The application of placebo did not cause a statistically significant change in nasal resistance, nasal airflow, and CSAs (CSA1, 2, and 3, respectively) of the nasal cavity. In contrast, statistically significant changes in nasal resistance (inspiration p=0.000 and p= 0.004; expiration p=0.000 and p=0.000), nasal airflow (inspiration p=0.000 and p= 0.004; expiration p=0.000 and p=0.000), and CSAs of the nasal cavity (CSA2 p=0.000 and p=0.000, CSA3 p=0.000 and p=0.00), with the exception of CSA1 (p= 0.982 and p=0.994), were obtained after the application of oxymetazoline and xylometazoline. A comparison of oxymetazoline and xylometazoline based on nasal resistance, nasal airflow, and CSAs of the nasal cavity demonstrated no statistically significant difference, except for CSA3. Conclusion: Oxymetazoline and xylometazoline are fast-acting and potent topical decongestants that have similar decongestive effects. © 2010 Springer-Verlag.
dc.identifier.DOI-ID10.1007/s00228-010-0941-z
dc.identifier.issn00316970
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18233
dc.language.isoEnglish
dc.subjectAdministration, Intranasal
dc.subjectAdult
dc.subjectFemale
dc.subjectHumans
dc.subjectImidazoles
dc.subjectMale
dc.subjectNasal Cavity
dc.subjectNasal Decongestants
dc.subjectNasal Mucosa
dc.subjectOxymetazoline
dc.subjectRhinitis, Vasomotor
dc.subjectRhinomanometry
dc.subjectRhinometry, Acoustic
dc.subjectYoung Adult
dc.subjectoxymetazoline
dc.subjectplacebo
dc.subjectxylometazoline
dc.subjectadult
dc.subjectarticle
dc.subjectdouble blind procedure
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman experiment
dc.subjectmale
dc.subjectnormal human
dc.subjectnose airflow
dc.subjectnose airway resistance
dc.subjectnose cavity
dc.subjectnose congestion
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectrhinomanometry
dc.subjectrhinometry
dc.titleA comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjects
dc.typeArticle

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