Metabolic comparison of radiolabeled bleomycin and bleomycin-glucuronide labeled with 99mTc

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dc.contributor.authorKoçan F.
dc.contributor.authorAvcíbaşí U.
dc.contributor.authorÜnak P.
dc.contributor.authorMüftüler F.Z.B.
dc.contributor.authorIçhedef Ç.A.
dc.contributor.authorDemiroǧlu H.
dc.contributor.authorGümüşer F.G.
dc.date.accessioned2024-07-22T08:19:58Z
dc.date.available2024-07-22T08:19:58Z
dc.date.issued2011
dc.description.abstractThe metabolic comparison of bleomycin (BLM) and bleomycin-glucuronide (BLMG) radiolabeled with 99mTc ( 99mTc-BLM and 99mTc-BLMG, respectively) has been investigated in this study. Quality control procedures were carried out using thin-layer radiochromatography and high-performance liquid chromatography. To compare the metabolic behavior of BLM and its glucuronide conjugate radiolabeled with 99mTc, scintigraphic, and biodistributional techniques were applied using male New Zealand rabbits and Albino Wistar rats. The results obtained have shown that these compounds were successfully radiolabeled with a labeling yield of about 100%. Maximum uptakes of 99mTc-BLM and 99mTc-BLMG metabolized as N-glucuronide were observed within 2 hours in the liver, the bladder, and the spinal cord for 99mTc-BLM and the lung, the liver, the kidney, the large intestine, and the spinal cord for 99mTc-BLMG, respectively. Scintigraphy and biodistributional studies performed on the experimental animals have shown that radiopharmaceutical potentials of these compounds are completely different. At the same time, uptake of the 99mTc-BLMG was found to be better than that of 99mTc-BLM. © 2011, Mary Ann Liebert, Inc.
dc.identifier.DOI-ID10.1089/cbr.2011.0998
dc.identifier.issn15578852
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17932
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectBleomycin
dc.subjectGlucuronides
dc.subjectHumans
dc.subjectMale
dc.subjectOrganotechnetium Compounds
dc.subjectRabbits
dc.subjectRadiopharmaceuticals
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTissue Distribution
dc.subjectbleomycin
dc.subjectglucuronide
dc.subjecttechnetium 99m
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbladder
dc.subjectcontrolled study
dc.subjectdrug distribution
dc.subjectdrug glucuronidation
dc.subjectdrug metabolism
dc.subjectdrug stability
dc.subjectdrug structure
dc.subjectlipophilicity
dc.subjectliver
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectscintigraphy
dc.subjectspinal cord
dc.titleMetabolic comparison of radiolabeled bleomycin and bleomycin-glucuronide labeled with 99mTc
dc.typeArticle

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