Serum and urinary nitric oxide in Type 2 diabetes with or without microalbuminuria: Relation to glomerular hyperfiltration

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dc.contributor.authorApakkan Aksun S.
dc.contributor.authorÖzmen B.
dc.contributor.authorÖzmen D.
dc.contributor.authorParildar Z.
dc.contributor.authorŞenol B.
dc.contributor.authorHabif S.
dc.contributor.authorMutaf I.
dc.contributor.authorTurgan N.
dc.contributor.authorBayindir O.
dc.date.accessioned2024-07-22T08:24:59Z
dc.date.available2024-07-22T08:24:59Z
dc.date.issued2003
dc.description.abstractBackground: Glomerular hyperfiltration is considered as one of the pathophysiological mechanisms for the development of diabetic nephropathy. Oxidative stress is enhanced in patients with diabetes mellitus. Reportedly, nitric oxide (NO) might be involved in the pathogenesis of hyperfiltration. We investigated the relationship between hyperfiltration and NO system, and malondialdehyde (MDA) levels in Type 2 diabetics with/without microalbuminuria. Methods: In 39 microalbuminuric, 29 normoalbuminuric Type 2 diabetic patients and 32 healthy controls, serum creatinine, nitrite, nitrate, urinary microalbumin, nitrite, nitrate, plasma MDA and estimated glomerular filtration rate (EGFR) values, calculated according to the Cockcroft and Gault formula, were recorded. Results: Serum and urine NO levels were higher in both microalbuminurics and normoalbuminurics than controls. There were no significant differences in EGFR between groups. However, hyperfiltration was determined in 31% of normoalbuminurics and 20% of microalbuminurics. Serum and urine NO levels were higher in patients with hyperfiltration. Plasma MDA levels were significantly elevated in both microalbuminurics and normoalbuminurics when compared with controls. Serum glucose and microalbuminuria were positively correlated in microalbuminuric diabetics. Serum NO levels were also positively correlated with EGFR in both normoalbuminurics and microalbuminurics. HbA1c levels were positively correlated with both urinary albumin excretion and plasma MDA levels in normoalbuminuric diabetics. Conclusion: Hyperglycemia is associated with an increased NO biosynthesis and lipid peroxidation. Increased oxidative stress may contribute to the high NO levels in Type 2 diabetes. Furthermore, the high NO levels may lead to hyperfiltration and hyperperfusion, which in turn leads to an increase in urinary albumin excretion and thus causes progression of nephropathy in early Type 2 diabetes. © 2003 Elsevier Inc. All rights reserved.
dc.identifier.DOI-ID10.1016/S1056-8727(02)00196-4
dc.identifier.issn10568727
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20216
dc.language.isoEnglish
dc.publisherElsevier Inc.
dc.subjectalbumin
dc.subjectcreatinine
dc.subjecthemoglobin A1c
dc.subjectmalonaldehyde
dc.subjectnitrate
dc.subjectnitric oxide
dc.subjectnitrite
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectblood level
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdiabetic nephropathy
dc.subjectfemale
dc.subjectglomerulus filtration
dc.subjectglomerulus filtration rate
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmicroalbuminuria
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectstatistical significance
dc.subjecturinary excretion
dc.subjecturine level
dc.titleSerum and urinary nitric oxide in Type 2 diabetes with or without microalbuminuria: Relation to glomerular hyperfiltration
dc.typeArticle

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