Antimicrobial susceptibility and resistance mechanisms of methicillin resistant Staphylococcus aureus isolated from 12 Hospitals in Turkey

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dc.contributor.authorYildiz T.
dc.contributor.authorÇoban A.Y.
dc.contributor.authorŞener A.G.
dc.contributor.authorCoşkuner S.A.
dc.contributor.authorBayramoğlu G.
dc.contributor.authorGüdücüoğlu H.
dc.contributor.authorÖzyurt M.
dc.contributor.authorTatman-Otkun M.
dc.contributor.authorKarabiber N.
dc.contributor.authorÖzkütük N.
dc.contributor.authorAktepe O.
dc.contributor.authorÖncü S.
dc.contributor.authorArslan U.
dc.contributor.authorBozdoğan B.
dc.date.accessioned2024-07-22T08:15:21Z
dc.date.available2024-07-22T08:15:21Z
dc.date.issued2014
dc.description.abstractIntroduction: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important nosocomial pathogens and is also emerging in Turkish hospitals. The aim of this study was to determine the antimicrobial susceptibility profiles of MRSA isolated from Turkish hospitals. Materials and methods: A total of 397 MRSA strains isolated from 12 hospitals in Turkey were included to present study. Antimicrobial susceptibilities were tested using agar dilution method. Presence of ermA, ermB, ermC, msrA, tetM, tetK, linA and aac-aph genes were studied by PCR. Results: All strains were susceptible to vancomycin and linezolid. The susceptibility rates for fusidic acid, lincomycin, erythromycin, tetracyclin, gentamycin, kanamycin, and, ciprofloxacin were 91.9%, 41.1%, 27.2%, 11.8%, 8.5%, 8.3% and 6.8%, respectively. Lincomycin inactivation was positive for 3 isolates. Of 225 erythromycin resistant isolates 48 had ermA, 20 had ermC, and 128 had ermA-C. PCR was negative for 15 strains. Of 3 isolates with lincomycin inactivation one had linA and msrA. Of 358 gentamycin resistant isolates 334 had aac-aph and 24 were negatives. Among 350 tetracyclin resistant isolates 314 had tetM. Of 36 tetM negative isolates 10 had tetK. Conclusion: MRSA isolates from Turkish hospitals were multiresistant to antimicrobials. Quinolone and gentamycin resistance levels were high and macrolide and lincosamide resistance were relatively low. Susceptibility rates for fusidic asid were high. Linezolide and vancomycin resistance are not emerged. The most common resistance genes were ermA, tetM and aac-aph. Evolution of antimicrobial susceptibilities and resistance genes profiles of MRSA isolates should be surveyed at regional and national level for accurate treatment of patients and to control dissemination of resistance genes. © 2014 Yildiz et al.; licensee BioMed Central Ltd.
dc.identifier.DOI-ID10.1186/s12941-014-0044-2
dc.identifier.issn14760711
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16720
dc.language.isoEnglish
dc.publisherBioMed Central Ltd.
dc.rightsAll Open Access; Gold Open Access
dc.subjectAnti-Bacterial Agents
dc.subjectCross Infection
dc.subjectDrug Resistance, Multiple, Bacterial
dc.subjectGenes, Bacterial
dc.subjectHospitals
dc.subjectHumans
dc.subjectMethicillin-Resistant Staphylococcus aureus
dc.subjectMicrobial Sensitivity Tests
dc.subjectPolymerase Chain Reaction
dc.subjectStaphylococcal Infections
dc.subjectTurkey
dc.subjectantibiotic agent
dc.subjectciprofloxacin
dc.subjecterythromycin
dc.subjectfusidic acid
dc.subjectgentamicin
dc.subjectlinezolid
dc.subjectmacrolide
dc.subjectmethionine sulfoxide reductase A
dc.subjectquinolone
dc.subjecttetracycline
dc.subjectvancomycin
dc.subjectantiinfective agent
dc.subjectagar dilution
dc.subjectantibiotic resistance
dc.subjectantibiotic sensitivity
dc.subjectArticle
dc.subjectbacterial gene
dc.subjectbacterial strain
dc.subjectbacterium isolate
dc.subjectcontrolled study
dc.subjectermA gene
dc.subjectermB gene
dc.subjectermC gene
dc.subjecthospital
dc.subjectlinA gene
dc.subjectlinB gene
dc.subjectmethicillin resistant Staphylococcus aureus
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectpolymerase chain reaction system
dc.subjecttetK gene
dc.subjecttetM gene
dc.subjectTurkey (republic)
dc.subjectcross infection
dc.subjectdrug effects
dc.subjectgenetics
dc.subjecthuman
dc.subjectisolation and purification
dc.subjectmethicillin resistant Staphylococcus aureus
dc.subjectmicrobial sensitivity test
dc.subjectmicrobiology
dc.subjectmultidrug resistance
dc.subjectpolymerase chain reaction
dc.subjectStaphylococcus infection
dc.subjectTurkey
dc.titleAntimicrobial susceptibility and resistance mechanisms of methicillin resistant Staphylococcus aureus isolated from 12 Hospitals in Turkey
dc.typeArticle

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