Fragmented QRS as a predictor of subclinical cardiovascular disease in patients with chronic kidney disease

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dc.contributor.authorToraman A.
dc.contributor.authorEren B.
dc.contributor.authorYılmaz I.
dc.contributor.authorDuzgun F.
dc.contributor.authorTaneli F.
dc.contributor.authorKursat S.
dc.date.accessioned2024-07-22T08:06:47Z
dc.date.available2024-07-22T08:06:47Z
dc.date.issued2020
dc.description.abstractBackground: Fragmented QRS (fQRS) on surface electrocardiogram is correlated with increased cardiovascular risk and mortality in normal population. Aims: To investigate the presence of fQRS and its association with subclinical atherosclerosis and vascular calcification in chronic kidney disease (CKD) patients without cardiovascular disease. Methods: A total of 129 CKD (63 males and 66 females) patients was enrolled for the study. Carotid intima-media thickness (CIMT) measurement and coronary artery calcification score (CACS) were performed by the same radiologist. A 12-lead electrocardiogram recording was used to detect fQRS. Results: The mean age was 55.1 ± 15.1 years. fQRS was detected in 45% of patients. There was not any significant difference between patients with or without fQRS in terms of demographic parameters and comorbid diseases except for diabetes and hyperlipidaemia. The mean CIMT of CKD patients was 0.66 ± 0.18 mm and it was significantly higher in fQRS(+) group compared to the fQRS(−) group. Similarly CACS values were higher in fQRS(+) group. In the logistic regression analysis, fQRS remained significantly associated with CIMT (β = 0.220, t = 2.567, P = 0.011) (independent variables: CIMT, CACS, sodium and glomerular filtration rate (modification of diet in renal disease–glomerular filtration rate)). Conclusions: This is the first study in the literature showing the relation of fQRS with CIMT and CACS in patients with CKD without known cardiovascular disease. © 2020 Royal Australasian College of Physicians
dc.identifier.DOI-ID10.1111/imj.14743
dc.identifier.issn14440903
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13697
dc.language.isoEnglish
dc.publisherBlackwell Publishing
dc.subjectAdult
dc.subjectAged
dc.subjectCardiovascular Diseases
dc.subjectCarotid Intima-Media Thickness
dc.subjectCoronary Artery Disease
dc.subjectElectrocardiography
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRenal Insufficiency, Chronic
dc.subjectRisk Factors
dc.subjectgrowth arrest specific protein 6
dc.subjectsodium
dc.subjectadult
dc.subjectage distribution
dc.subjectArticle
dc.subjectatherosclerosis
dc.subjectcardiovascular disease
dc.subjectcarotid intima-media thickness
dc.subjectchronic kidney failure
dc.subjectcomorbidity
dc.subjectcontrolled study
dc.subjectcoronary artery calcification
dc.subjectcoronary artery calcium score
dc.subjectdemography
dc.subjectdiabetes mellitus
dc.subjectECG abnormality
dc.subjectelectrocardiography
dc.subjectfemale
dc.subjectfragmented QRS complex
dc.subjectglomerulus filtration rate
dc.subjecthuman
dc.subjecthyperlipidemia
dc.subjectlogistic regression analysis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmodification of diet in renal disease glomerular filtration rate
dc.subjectprediction
dc.subjectpriority journal
dc.subjectQRS complex
dc.subjectradiologist
dc.subjectrisk factor
dc.subjectaged
dc.subjectarterial wall thickness
dc.subjectcardiovascular disease
dc.subjectchronic kidney failure
dc.subjectcomplication
dc.subjectcoronary artery disease
dc.subjectmiddle aged
dc.subjectrisk factor
dc.titleFragmented QRS as a predictor of subclinical cardiovascular disease in patients with chronic kidney disease
dc.typeArticle

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