Significance of tyrosine kinase activity on malign transformation of ovarian tumors: A comparison between EGF-R and TGF-α

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dc.contributor.authorZeren T.
dc.contributor.authorInan S.
dc.contributor.authorSeda Vatansever H.
dc.contributor.authorEkerbicer N.
dc.contributor.authorSayhan S.
dc.date.accessioned2024-07-22T08:22:18Z
dc.date.available2024-07-22T08:22:18Z
dc.date.issued2008
dc.description.abstractEpidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α) are members of the polypeptide growth factor family. The epidermal growth factor-receptor (EGF-R) is a receptor tyrosine kinase of the ErbB family. Many types of cancer, including ovarian cancer, display enhanced EGF-R immunoreactivity on their cell surface membranes. Also, an increase in TGF-α synthesis and secretion usually occurs in human carcinoma cell lines. In this study, we compared the immunoreactivities of TGF-α and EGF-R in ovarian tumors and related immunohistochemical findings to the histological type of the tumors. Formalin-fixed, paraffin wax-embedded tissue sections from 40 patients who had serous-mucinous borderline tumor and serous-mucinous adenocarcinoma of the ovary (n=10 each) were stained with hematoxylin-eosin and labeled for binding of primary antibodies against TGF-α and EGF-R using an avidin-biotin-peroxidase method. A semi-quantitative grading system was used to compare immunohistochemical labeling intensities. Increased immunoreactivity of EGF-R and moderate immunoreactivity of TGF-α was detected in adenocarcinomas. There was no significant difference in the immunoreactivity of TGF-α among the histologic types of ovarian tumors. The results of this study support the hypothesis that EGF-R may be a more useful marker than TGF-α in epithelial ovarian tumors. © 2007 Elsevier GmbH. All rights reserved.
dc.identifier.DOI-ID10.1016/j.acthis.2007.08.007
dc.identifier.issn00651281
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19020
dc.language.isoEnglish
dc.publisherElsevier GmbH
dc.subjectepidermal growth factor receptor
dc.subjectprotein tyrosine kinase
dc.subjecttransforming growth factor alpha
dc.subjectadult
dc.subjectarticle
dc.subjectcell surface
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdiagnostic value
dc.subjectdisease marker
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmalignant transformation
dc.subjectovary adenocarcinoma
dc.subjectovary cancer
dc.subjectovary tumor
dc.subjectprotein secretion
dc.subjectquantitative analysis
dc.subjectstaining
dc.subjecttissue fixation
dc.titleSignificance of tyrosine kinase activity on malign transformation of ovarian tumors: A comparison between EGF-R and TGF-α
dc.typeArticle

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