Prevalence of cardiovascular diseases and traditional cardiovascular risk factors in patients with rheumatoid arthritis: a real-life evidence from BioSTAR nationwide registry

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dc.contributor.authorDuruöz M.T.
dc.contributor.authorAtaman Ş.
dc.contributor.authorBodur H.
dc.contributor.authorÇay H.F.
dc.contributor.authorMelikoğlu M.A.
dc.contributor.authorAkgül Ö.
dc.contributor.authorÇapkın E.
dc.contributor.authorGürer G.
dc.contributor.authorÇevik R.
dc.contributor.authorGöğüş F.N.
dc.contributor.authorKamanlı A.
dc.contributor.authorYurdakul F.G.
dc.contributor.authorYağcı I.
dc.contributor.authorRezvani A.
dc.contributor.authorAltan L.
dc.date.accessioned2024-07-22T08:01:35Z
dc.date.available2024-07-22T08:01:35Z
dc.date.issued2024
dc.description.abstractPatients with rheumatoid arthritis (RA) have increased morbidity and mortality due to cardiovascular (CV) comorbidities. The association of CV diseases (CVD) and traditional CV risk factors has been debated, depending on patient and RA characteristics. This study aimed to find the prevalence of CVD and CV risk factors in patients with RA. A multi-center cross-sectional study was performed on RA patients using the BioSTAR (Biological and Targeted Synthetic Disease-Modifying Antirheumatic Drugs Registry) in September 2022. Socio-demographic, clinical, and follow-up data were collected. Myocardial infarction, ischemic heart disease, peripheral vascular disorders, congestive heart failure, ischemic stroke, and transient ischemic attack were regarded as major adverse cardiovascular events (MACEs). CVD was defined as the presence of at least one clinical situation of MACE. Group 1 and Group 2 included patients with and without CVD. Prevalence rates of CVD and traditional CV risk factors were the primary outcomes. Secondary outcomes were the differences in the clinical characteristics between patients with and without CVD. An analysis of 724 patients with a mean age of 55.1 ± 12.8 years diagnosed with RA was conducted. There was a female preponderance (79.6%). The prevalence rate of CVD was 4.6% (n = 33). The frequencies of the diseases in the MACE category were ischemic heart disease in 27, congestive heart failure in five, peripheral vascular disorders in three, and cerebrovascular events in three patients. The patients with CVD (Group 1) were significantly male, older, and had higher BMI (p = 0.027, p < 0.001, and p = 0.041). Obesity (33.4%) and hypertension (27.2%) were the two CV risk factors most frequently. Male sex (HR = 7.818, 95% CI 3.030–20.173, p < 0.001) and hypertension (HR = 4.570, 95% CI 1.567–13.328, p = 0.005) were the independent risk factors for CVD. The prevalence of CVD in RA patients was 4.6%. Some common risk factors for CVD in the general population, including male sex, older age, and hypertension, were evident in RA patients. Male sex and hypertension were the independent risk factors for developing CVD in patients with RA. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s00296-023-05515-y
dc.identifier.issn01728172
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11505
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.subjectAdult
dc.subjectAged
dc.subjectArthritis, Rheumatoid
dc.subjectCardiovascular Diseases
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHeart Disease Risk Factors
dc.subjectHeart Failure
dc.subjectHumans
dc.subjectHypertension
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPrevalence
dc.subjectRegistries
dc.subjectRisk Factors
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectArticle
dc.subjectcardiovascular disease
dc.subjectcardiovascular risk
dc.subjectcardiovascular risk factor
dc.subjectcerebrovascular accident
dc.subjectcomorbidity
dc.subjectcongestive heart failure
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdiagnosis
dc.subjectfemale
dc.subjectfollow up
dc.subjectGermany
dc.subjectheart infarction
dc.subjecthuman
dc.subjecthypertension
dc.subjectischemic heart disease
dc.subjectmajor adverse cardiac event
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmorbidity
dc.subjectmortality
dc.subjectobesity
dc.subjectperipheral vascular disease
dc.subjectprevalence
dc.subjectrheumatoid arthritis
dc.subjectrisk factor
dc.subjectsecondary prevention
dc.subjecttransient ischemic attack
dc.subjectcardiovascular disease
dc.subjectcomplication
dc.subjectheart disease risk factor
dc.subjectheart failure
dc.subjecthypertension
dc.subjectmiddle aged
dc.subjectprevalence
dc.subjectregister
dc.subjectrheumatoid arthritis
dc.titlePrevalence of cardiovascular diseases and traditional cardiovascular risk factors in patients with rheumatoid arthritis: a real-life evidence from BioSTAR nationwide registry
dc.typeArticle

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