Atherosclerosis risk factors in children of parents with the metabolic syndrome

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dc.contributor.authorAkinci G.
dc.contributor.authorCoskun S.
dc.contributor.authorAkinci B.
dc.contributor.authorHekimsoy Z.
dc.contributor.authorBayindir P.
dc.contributor.authorOnur E.
dc.contributor.authorOzmen B.
dc.date.accessioned2024-07-22T08:22:47Z
dc.date.available2024-07-22T08:22:47Z
dc.date.issued2007
dc.description.abstractBackground: Metabolic syndrome is a constellation of disorders that produces a high risk of atherosclerosis. Endothelial dysfunction is the key event in atherosclerosis and already present even in the childhood. The aim of the present study is to investigate inflammatory and radiological signs of atherosclerosis in children who have parents with the metabolic syndrome. Design and methods: Fifty children of parents with the metabolic syndrome and 38 age- and sex-matched controls were studied. Anthropometric measurements, blood pressure assessment, echocardiography, flow-mediated vasodilatation (FMD) which is a non-invasive test for the evaluation of endothelial function and fasting blood measurements including blood glucose, insulin, total cholesterol, HDL cholesterol, triglyceride, hsCRP and soluble CD40 ligand were performed. Results: Serum sCD40L and hsCRP levels were significantly higher in the study group compared to the controls. FMD values did not differ between the study and control groups. Increased serum sCD40L levels were positively correlated with body mass index, waist hip ratio, LDL/HDL cholesterol ratio, and the number of metabolic syndrome components in parents, whereas showed negative correlation with the serum HDL cholesterol levels. High hsCRP levels were positively correlated with body mass index and the number of metabolic syndrome components. Multiple regression analysis demonstrated that the number of metabolic syndrome components in parents presented as being a significant predictor of the serum sCD40L and hsCRP levels of their children. Conclusion: Our results suggest that children of patients with metabolic syndrome have higher values of the serum markers of inflammation, which may be associated with increased risk for development of cardiovascular disease. © 2007 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.DOI-ID10.1016/j.atherosclerosis.2006.12.008
dc.identifier.issn00219150
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19245
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAtherosclerosis
dc.subjectBiological Markers
dc.subjectBody Mass Index
dc.subjectC-Reactive Protein
dc.subjectCase-Control Studies
dc.subjectCD40 Ligand
dc.subjectChild
dc.subjectFemale
dc.subjectHumans
dc.subjectInflammation
dc.subjectMale
dc.subjectMetabolic Syndrome X
dc.subjectParents
dc.subjectRisk Factors
dc.subjectStatistics as Topic
dc.subjectVasodilation
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectCD40 ligand
dc.subjectcholesterol
dc.subjectglucose
dc.subjecthigh density lipoprotein cholesterol
dc.subjectinsulin
dc.subjectlow density lipoprotein
dc.subjecttriacylglycerol
dc.subjectadolescent
dc.subjectanthropometry
dc.subjectarticle
dc.subjectatherosclerosis
dc.subjectblood flow
dc.subjectblood pressure measurement
dc.subjectbody mass
dc.subjectcardiovascular risk
dc.subjectcholesterol blood level
dc.subjectclinical article
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectdiet restriction
dc.subjectechocardiography
dc.subjectfamily history
dc.subjectfemale
dc.subjectglucose blood level
dc.subjecthigh risk population
dc.subjecthuman
dc.subjectinflammation
dc.subjectinsulin blood level
dc.subjectmale
dc.subjectmetabolic syndrome X
dc.subjectmultiple regression
dc.subjectnon invasive procedure
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectradiodiagnosis
dc.subjectschool child
dc.subjecttriacylglycerol blood level
dc.subjectvascular endothelium
dc.subjectvasodilatation
dc.subjectwaist hip ratio
dc.titleAtherosclerosis risk factors in children of parents with the metabolic syndrome
dc.typeArticle

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