Long-term outcomes of thymosin-α1 and interferon α-2b combination therapy in patients with hepatitis B e antigen (HBeAg) negative chronic hepatitis B

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dc.contributor.authorSaruc M.
dc.contributor.authorOzden N.
dc.contributor.authorTurkel N.
dc.contributor.authorAyhan S.
dc.contributor.authorHock L.M.
dc.contributor.authorTuzcuoglu I.
dc.contributor.authorYuceyar H.
dc.date.accessioned2024-07-22T08:24:43Z
dc.date.available2024-07-22T08:24:43Z
dc.date.issued2003
dc.description.abstractHepatitis B e antibody (HbeAb) and hepatitis B virus (HBV) DNA positive chronic hepatitis is a clinical entity, distinct from classical hepatitis B e antigen (HbeAg) positive chronic hepatitis B. Our aim was to evaluate the long-term therapeutic efficacy of the combination of interferon α-2b and thymosin-α1 compared with lamivudine plus interferon α-2b and interferon α-2b alone. Fifty-two patients with HbeAg-negative chronic hepatitis B were assigned to three different groups in a nonrandomized manner. Group 1 (n = 27) received thymosin-α1 [1.6 mg subcutaneously (sc), twice a week] and interferon α-2b (10 MIU sc, three times per week) for 26 weeks, subsequently followed by interferon α-2b monotherapy at the same dosage for an additional 26 weeks. Group 2 (n = 10) received interferon α-2b (10 MIU sc, three times per week) for 52 weeks. Group 3 (n = 15) received interferon α-2b (10 MIU sc, three times per week) and lamivudine [100 mg orally (po), q.d.] for 52 weeks, followed by continuous lamivudine (100 mg po, q.d.) therapy. By the end of 78 weeks, a sustained response (SR-6 mo) was seen in 74% (20/27) of the patients within Group 1. On the contrary, Groups 2 and 3 had sustained response rates of 40 (4/10) and 53.3% (8/15), respectively (p = 0.13). At the end of 12 months post-treatment in Group 1, a virological and biochemical response rate was seen in 70.3% of patients (19/27); in contrast, Groups 2 and 3 had response rates of 20 (2/10) and 26.6% (4/15), respectively (p = 0036). At the end of the 18-month post-treatment follow-up period, 71.4% (19/27) of patients in Group 1, 10% of patients in Group 2 (1/10), and 20% of patients in Group 3(3/15) preserved their sustained response (p = 0.0003). Interferon α-2b and thymosin-α1 combination therapy results in significant virological and biochemical response rates compared with standard therapeutic regimens and is well tolerated. © 2003 Wiley-Liss, Inc. and the American Pharmacists Association.
dc.identifier.DOI-ID10.1002/jps.10401
dc.identifier.issn00223549
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20077
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc.
dc.subjectalpha2b interferon
dc.subjecthepatitis B surface antigen
dc.subjecthepatitis B(e) antigen
dc.subjectlamivudine
dc.subjectrecombinant alpha2b interferon
dc.subjectthymosin alpha1
dc.subjectadult
dc.subjectantiviral activity
dc.subjectarticle
dc.subjectchronic hepatitis
dc.subjectdepression
dc.subjectdrug effect
dc.subjectdrug safety
dc.subjectfemale
dc.subjectfever
dc.subjectflu like syndrome
dc.subjecthepatitis B
dc.subjecthuman
dc.subjectimmune response
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectneutropenia
dc.subjectoutcomes research
dc.subjectthrombocytopenia
dc.subjectvirus replication
dc.titleLong-term outcomes of thymosin-α1 and interferon α-2b combination therapy in patients with hepatitis B e antigen (HBeAg) negative chronic hepatitis B
dc.typeArticle

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