Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein

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dc.contributor.authorKoç, S
dc.contributor.authorSen, S
dc.contributor.authorTerzi, Y
dc.contributor.authorKizilay, F
dc.contributor.authorDemir, S
dc.contributor.authorAksoy, DB
dc.contributor.authorKurtulus, F
dc.contributor.authorBilge, N
dc.contributor.authorIdilman, E
dc.contributor.authorUzunköprü, C
dc.contributor.authorGüngör, S
dc.contributor.authorÇilingir, V
dc.contributor.authorEthemoglu,Ö
dc.contributor.authorBoz, C
dc.contributor.authorGümüs, H
dc.contributor.authorKiliç, AK
dc.contributor.authorKisabay, A
dc.contributor.authorBir, LS
dc.contributor.authorTuran, ÖF
dc.contributor.authorSoysal, A
dc.contributor.authorKöseoglu, M
dc.contributor.authorUzuner, GT
dc.contributor.authorBayindir, H
dc.contributor.authorKabay, SC
dc.contributor.authorÇam, M
dc.contributor.authorYayla, V
dc.contributor.authorTan, HY
dc.contributor.authorÖzcan, A
dc.contributor.authorTaskapioglu,Ö
dc.contributor.authorKorkmaz, M
dc.contributor.authorTamam, Y
dc.contributor.authorInanç, Y
dc.contributor.authorEfendi, H
dc.contributor.authorKotan, D
dc.contributor.authorYetkin, MF
dc.contributor.authorBilgiç, AB
dc.contributor.authorSaçmaci, H
dc.contributor.authorDemirci, S
dc.contributor.authorÇelik, Y
dc.contributor.authorPoyraz, T
dc.contributor.authorTerzi, M
dc.date.accessioned2025-04-10T10:37:51Z
dc.date.available2025-04-10T10:37:51Z
dc.description.abstractBackground: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited. Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG. Study Design: Multicenter, retrospective, observational study. Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz May & imath;s University's Faculty of Medicine were included in the study. Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients. Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.
dc.identifier.e-issn2146-3131
dc.identifier.issn2146-3123
dc.identifier.urihttp://hdl.handle.net/20.500.14701/43238
dc.language.isoEnglish
dc.titleClinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein
dc.typeArticle

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