Relation between vascular endothelial markers and right ventricular function in the children with asthma

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dc.contributor.authorCetin M.
dc.contributor.authorKaraboga B.
dc.contributor.authorYilmaz O.
dc.contributor.authorYilmaz M.
dc.contributor.authorYuksel H.
dc.contributor.authorCoskun S.
dc.date.accessioned2024-07-22T08:10:20Z
dc.date.available2024-07-22T08:10:20Z
dc.date.issued2017
dc.description.abstractObjectives: The aim of the study was to evaluate the possible relationship of clinical severity during asthmatic exacerbation with the ventricular functions and the levels of vascular endothelial-related biomarkers endothelin-1 (ET-1) and platelet-derived growth factor-BB (PDGF-BB) in the condensed breathing air in the children with asthma. Methods: The study included a total of 80 children with acute asthmatic episode; of these, 28 had a mild, 26 had a moderate, and 26 had a severe attack. Samples of condensed breathing air were obtained for being analyzed for ET-1 and PDGF-BB levels during the study. All patients were evaluated by echocardiography at the beginning of the study and two weeks after the treatment of asthmatic episode. Results: Before treatment, mPAP in moderate and severe asthma groups was significantly higher than in mild asthma group (21.6 ± 7.3, 30.1 ± 9.8 and 32.7 ± 7.8; P < 0.01, P < 0.001, respectively). After treatment, no significant difference was detected between the asthma groups (P > 0.05). Am and Em waves, and IVRT, IVCT, ET and RV MPI during the asthmatic attack and after treatment did not change significantly between the groups; pre- and post-treatment values of these parameters also did not show significant differences. In exhaled air samples of the group with severe asthma exacerbation ET-1 and PDGF-BB were higher than those in the moderate and mild group (0.80 ± 0.42, 0.58 ± 0.30, 0.50 ± 0.15; P = 0.002 and 281.7 ± 253.2, 167.3 ± 148.1, 135.9 ± 74.9; P = 0.008 respectively). Conclusions: Ourstudy resultsshowedthatmPAPin direct proportion with the increasedinflammatory cytokineswassignificantly higher in asthma attacks and levels of ET-1 and PDGF-BB were significantly increased with severity of asthma, indicating a vascular response. © 2017, Iranian Journal of Pediatrics.
dc.identifier.DOI-ID10.5812/ijpbs.9363
dc.identifier.issn20082142
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15181
dc.language.isoEnglish
dc.publisherTehran University of Medical Sciences
dc.rightsAll Open Access; Gold Open Access
dc.subjectendothelin 1
dc.subjectplatelet derived growth factor BB
dc.subjectadolescent
dc.subjectallergic rhinitis
dc.subjectArticle
dc.subjectasthma
dc.subjectcardiovascular parameters
dc.subjectchild
dc.subjectcontrolled study
dc.subjectcorrelational study
dc.subjectcross-sectional study
dc.subjectdisease exacerbation
dc.subjectdisease severity
dc.subjectDoppler echocardiography
dc.subjectfemale
dc.subjectfollow up
dc.subjectheart performance
dc.subjectheart right ventricle endsystolic volume
dc.subjectheart right ventricle function
dc.subjectheart ventricle ejection time
dc.subjectheart ventricle size
dc.subjecthuman
dc.subjectisovolumic contraction time
dc.subjectisovolumic relaxation time
dc.subjectlung artery pressure
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpeak early diastolic myocardial annular velocity
dc.subjectpeak late diastolic myocardial annular velocity
dc.subjectpulmonary acceleration time
dc.subjectrespiratory tract parameters
dc.subjecttissue Doppler imaging
dc.titleRelation between vascular endothelial markers and right ventricular function in the children with asthma
dc.typeArticle

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