Adulthood asthma as a consequence of childhood adversity: A systematic review of epigenetically affected genes

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dc.contributor.authorSaygideger Y.
dc.contributor.authorÖzkan H.
dc.contributor.authorBaydar O.
dc.contributor.authorYilmaz O.
dc.date.accessioned2024-07-22T08:03:43Z
dc.date.available2024-07-22T08:03:43Z
dc.date.issued2022
dc.description.abstractThere is an accumulating data that shows relation between childhood adversity and vulnerability to chronic diseases as well as epigenetic influences that in turn give rise to these diseases. Asthma is one of the chronic diseases that is influenced from genetic regulation of the inflammatory biomolecules and therefore the hypothesis in this research was childhood adversity might have caused epigenetic differentiation in the asthma-related genes in the population who had childhood trauma. To test this hypothesis, the literature was systematically reviewed to extract epigenetically modified gene data of the adults who had childhood adversity, and affected genes were further evaluated for their association with asthma. PRISMA guidelines were adopted and PubMed and Google Scholar were included in the searched databases, to evaluate epigenetic modifications in asthma-related genes of physically, emotionally or sexually abused children. After retrieving a total of 5245 articles, 36 of them were included in the study. Several genes and pathways that may contribute to pathogenesis of asthma development, increased inflammation, or response to asthma treatment were found epigenetically affected by childhood traumas. Childhood adversity, causing epigenetic changes in DNA, may lead to asthma development or influence the course of the disease and therefore should be taken into account for the prolonged health consequences. © 2022 The Author(s). Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease.
dc.identifier.DOI-ID10.1017/S2040174422000083
dc.identifier.issn20401744
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12411
dc.language.isoEnglish
dc.publisherCambridge University Press
dc.rightsAll Open Access; Green Open Access
dc.subjectAdult
dc.subjectAdverse Childhood Experiences
dc.subjectAsthma
dc.subjectChild
dc.subjectEpigenesis, Genetic
dc.subjectHumans
dc.subjectInflammation
dc.subjectadult
dc.subjectasthma
dc.subjectchild
dc.subjectgenetic epigenesis
dc.subjectgenetics
dc.subjecthuman
dc.subjectinflammation
dc.titleAdulthood asthma as a consequence of childhood adversity: A systematic review of epigenetically affected genes
dc.typeArticle

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