Imiquimod 5% cream for isolated lichen planus of the lip

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dc.contributor.authorGencoglan G.
dc.contributor.authorNanir S.
dc.contributor.authorSahin O.
dc.contributor.authorGunduz K.
dc.date.accessioned2024-07-22T08:20:22Z
dc.date.available2024-07-22T08:20:22Z
dc.date.issued2011
dc.description.abstractLichen planus (LP) of the lips is a rare condition that is generally associated with other parts of the oral mucosa. Lip localization has an increased risk, since external trauma, smoking and ultraviolet light trigger malignant transformation. Only a few cases of isolated LP of the lips have been reported up to now, but results of larger series on oral LP suggest that it might be underestimated. Treatment of oral LP is usually difficult and lesions are generally resistant or recur, so that novel therapy alternatives are necessary. Here we report four cases of isolated LP of the lip successfully treated with imiquimod 5% cream. It was applied twice daily, 5 days a week, for 2 weeks. Two weeks after therapy, complete clinical and histopathological resolution was observed. No recurrence was observed during the 5, 10 and 18 months' follow-up period in cases 4, 3 and 1, respectively. Clinical and histopathological cure was also observed in case 2, but the patient showed clinical activation after 6 months. We suggest that imiquimod 5% cream is a safe and effective therapeutic treatment for oral LP. © 2011 Informa Healthcare USA on behalf of Informa UK Ltd.
dc.identifier.DOI-ID10.3109/09546630903456367
dc.identifier.issn14711753
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18122
dc.language.isoEnglish
dc.subjectAdministration, Topical
dc.subjectAdult
dc.subjectAged
dc.subjectAminoquinolines
dc.subjectHumans
dc.subjectInterferon Inducers
dc.subjectLichen Planus, Oral
dc.subjectLip Diseases
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectYoung Adult
dc.subjectcorticosteroid
dc.subjectimiquimod
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectcase report
dc.subjectcream
dc.subjecterosion
dc.subjecterythema
dc.subjectfollow up
dc.subjecthistopathology
dc.subjecthuman
dc.subjectlichen planus
dc.subjectlip
dc.subjectmale
dc.subjectpriority journal
dc.subjectskin biopsy
dc.subjectsmoking habit
dc.titleImiquimod 5% cream for isolated lichen planus of the lip
dc.typeArticle

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