Assessment of alveolar epithelial permeability in Behçet's disease with 99mTc-DTPA aerosol scintigraphy

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dc.contributor.authorGumuser F.G.
dc.contributor.authorPirildar T.
dc.contributor.authorBatok D.
dc.contributor.authorSakar A.
dc.contributor.authorRuksen E.
dc.contributor.authorSayit E.
dc.date.accessioned2024-07-22T08:22:15Z
dc.date.available2024-07-22T08:22:15Z
dc.date.issued2008
dc.description.abstractObjective: Behçet's disease (BD) is a multisystem disorder characterized by vasculitis, and consists of a triad of recurrent ulcers of the oral and genital mucosa with relapsing uveitis. The prevalance of pulmonary involvement varies in the range of 1-10% in various studies and its complications are severe and life threatening. In this study, we investigated the changes of pulmonary epithelial permeability of patients with BD using technetium-99m diethylene triamine penta-acetic acid (99mTc-DTPA) aerosol scintigraphy, so as to begin the therapy regimen as soon as possible. Methods: Twenty-one nonsmoking patients with BD (8 women, 13 men; mean age 38.67 ± 8.86 years) and 15 healthy volunteer nonsmoking controls (8 women, 7 men; mean age 50.87 ± 12.45 years) underwent 99mTc-DTPA aerosol inhalation scintigraphy and pulmonary function tests (PFTs). Subjects inhaled 1480 MBq of 99mTc-DTPA for 4 min in the supine position. Scintigraphic data were recorded dynamically (1 frame/min) in the posterior projection on a 64 × 64 matrix for a 30-min period using a double-headed gamma camera (Infinia, GE, Tirat Hacarmel, Israel) equipped with a low-energy all-purpose parallel hole collimator. Half time of 99mTc-DTPA clearance (T 1/2) was calculated by placing a mono-exponential fit on the curves. Penetration index (PI) was also calculated by dividing the peripheral total counts by the sum of the peripheral and central total counts on the first minute image, in order to quantify the distribution of the inhaled aerosol. Results: The clearance half time of 99mTc-DTPA radioaerosols in the BD patients (24.81 ± 6.22 min) was faster than in the normal control group (46.53 ± 22.41 min) (P = 0.004). There was also a significant difference between PI of the patients with BD (0.15 ± 0.03) and that of the controls (0.21 ± 0.06) (P = 0.002). No correlation was found between the mean T 1/2 values of 99mTc-DTPA clearance or the spirometric measurements in the BD patients. Penetration indices were not correlated with PFT in the BD patients. Conclusions: Lung epithelial permeability of the patients with BD was significantly higher than that of the normal subjects. The results of this study demonstrated that the assessment of lung epithelial permeability using 99mTc-DTPA aerosol scintigraphy could predict the presence of lung involvement in the early stages of BD. © 2008 The Japanese Society of Nuclear Medicine.
dc.identifier.DOI-ID10.1007/s12149-007-0138-4
dc.identifier.issn09147187
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18975
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAerosols
dc.subjectBehcet Syndrome
dc.subjectFemale
dc.subjectHumans
dc.subjectImage Interpretation, Computer-Assisted
dc.subjectMale
dc.subjectPermeability
dc.subjectPulmonary Alveoli
dc.subjectRadiopharmaceuticals
dc.subjectReproducibility of Results
dc.subjectRespiratory Mucosa
dc.subjectSensitivity and Specificity
dc.subjectTechnetium Tc 99m Pentetate
dc.subjectpentetate technetium tc 99m
dc.subjectadult
dc.subjectarticle
dc.subjectBehcet disease
dc.subjectclinical article
dc.subjectclinical assessment
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjectimage analysis
dc.subjectlung alveolus epithelium
dc.subjectlung function test
dc.subjectlung injury
dc.subjectlung scintiscanning
dc.subjectmale
dc.subjectpriority journal
dc.subjectthorax radiography
dc.titleAssessment of alveolar epithelial permeability in Behçet's disease with 99mTc-DTPA aerosol scintigraphy
dc.typeArticle

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