Albendazole as an alternative therapeutic agent for childhood giardiasis in Turkey
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2004
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Abstract
The efficacy of albendazole for the treatment of giardiasis has been indicated by previous in-vitro and in-vivo studies. In order to compare the therapeutic efficacy of albendazole and metronidazole, 107 Giardia-positive children (aged 3-15 years), diagnosed by three consecutive positive stool examinations, were enrolled in the study. Of these children, 52 were given a single daily dose of albendazole 10 mg/kg for 5 days, and 55 were given metronidazole 20 mg/kg daily in three doses for 7 days. Parasite eradication was achieved in 47 (90.4%) of 52 children treated with albendazole and 49 (89.1%) of 55 children treated with metronidazole (p > 0.05). These results suggest that albendazole is an effective treatment option for childhood giardiasis. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.
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Giardia , Giardia intestinalis , albendazole , benzimidazole derivative , mepacrine , metronidazole , adolescent , article , child , childhood disease , controlled study , drug dose regimen , drug efficacy , drug safety , eradication therapy , feces analysis , Giardia lamblia , giardiasis , human , in vitro study , in vivo study , major clinical study , priority journal , single drug dose , statistical significance , Turkey (republic)