Histologic and physiologic analysis of the relationship between the dorsal nerve of the penis and the corpus cavernosum on a rat model. A complementary pathway on the innervation of penile erection?

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dc.contributor.authorKozacioglu Z.
dc.contributor.authorVatansever H.S.
dc.contributor.authorOnal T.
dc.contributor.authorKutlu N.
dc.contributor.authorOzel F.
dc.contributor.authorGunlusoy B.
dc.contributor.authorGumus B.H.
dc.date.accessioned2024-07-22T08:05:06Z
dc.date.available2024-07-22T08:05:06Z
dc.date.issued2022
dc.description.abstractAim: The dorsal nerve of the penis (DNP) is the terminal branch of the pudendal nerve which is responsible for the somatic innervation of the penis. This study aims to outline any direct role of the DNP in the hemodynamics of erection histologically and physiologically. Materials and Methods: Fifteen Wistar albino rats were sorted into the electrical activity (n = 6), intracavernous pressure (n = 4), and control (n = 5) groups. The dorsal nerve was electrostimulated and the simultaneous changes in intracavernous pressure and smooth muscle activity were recorded. Penile tissues were collected, fixed, and sectioned, the slides were stained with either hematoxylin-eosin for morphological evaluation or using the indirect immunoperoxidase technique to analyze the distributions of eNOS, iNOS, and nNOS. Results: During electrostimulation, there was a simultaneous statistically significant decrease in the electrical activity inside the corpora in electromyography and an increase in intracavernous pressure. eNOS and iNOS immunoreactivities were higher in the study group than in the control group. nNOS immunoreactivity was moderate in both study and control groups. Conclusion: Some fibers in the dorsal nerve of penis continue into the corpora cavernosa through the tunica albuginea and have an active, direct role in the hemodynamic process of erection, which may be complementary to the main route of innervation. © 2021 Wiley Periodicals LLC.
dc.identifier.DOI-ID10.1002/nau.24829
dc.identifier.issn07332467
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12973
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc
dc.subjectAnimals
dc.subjectMale
dc.subjectMuscle, Smooth
dc.subjectPenile Erection
dc.subjectPenis
dc.subjectPudendal Nerve
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectendothelial nitric oxide synthase
dc.subjectinducible nitric oxide synthase
dc.subjectneuronal nitric oxide synthase
dc.subjectperoxidase
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectcorpus cavernosum
dc.subjectdorsal root
dc.subjectelectric activity
dc.subjectelectromyography
dc.subjectelectrostimulation
dc.subjecthemodynamics
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectintracavernous pressure
dc.subjectnonhuman
dc.subjectpenis erection
dc.subjectrat
dc.subjectsmooth muscle contractility
dc.subjecttunica albuginea
dc.subjectWistar rat
dc.subjectanimal
dc.subjectinnervation
dc.subjectmale
dc.subjectpenis
dc.subjectphysiology
dc.subjectpudendal nerve
dc.subjectsmooth muscle
dc.titleHistologic and physiologic analysis of the relationship between the dorsal nerve of the penis and the corpus cavernosum on a rat model. A complementary pathway on the innervation of penile erection?
dc.typeArticle

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