Interactions of thyroid hormones; Insulin-like growth factor-1 (IGF-1), igf binding proteins, and nutritional anthropometric parameters in school children with goiter detected by palpation

Simple item page
dc.contributor.authorErsoy B.
dc.contributor.authorGunes H.S.
dc.contributor.authorUyanik B.S.
dc.contributor.authorTaneli F.
dc.contributor.authorGunay T.
dc.date.accessioned2024-07-22T08:21:28Z
dc.date.available2024-07-22T08:21:28Z
dc.date.issued2009
dc.description.abstractAim: In the present study we evaluated anthropometric indices, serum thyroid hormones, insulin-like growth factor-1 (IGF-1) and IGF- binding proteins (IGFBPs) levels, in children who has palpable goiter at endemic population. We aimed to 1) compare children with palpable goiter with healthy peers, 2) detect interaction of anthropometric indices, serum thyroid hormones, IGF-1 and IGFBPs parameters in both groups 3) evaluate the effects of their nutritional status to these parameters. Subjects and Methods: We performed goiter palpation to 1018 child and found goiter at 81 child. Seventy-three pubertal children were included in this study. Seventy-five healthy children were defined as the control group. Weight and height of all children were measured. Thyroid hormone levels, IGF-1, IGFBP-3, and IGFBP-1 were assessed in both groups. Results: Height and weight SDS were significantly lower in children who had goiter by palpation than healthy peers (p<0.05). Free T4 (FT4) levels were significantly higher in control group than children with palpable goiter (p<0.05). IGF-1 level and IGF-1 SDS were significantly lower in children with palpable goiter (p<0.001), IGFBP3 and IGFBP1 levels were not significantly different between the two groups (p>0.05). Serum IGF-1 and IGFBP-3 levels were significantly lower (p<0.05) in underweight children with goiter than normal weight group. In the presence of goiter, IGF-1 levels were lower (B: 0.97, 95% CI: 0.960.98, p<0.001). Conclusion: In endemic areas, children with palpable goiter were shorter and thinner than the healthy peers. Thyroid hormones were between the reference ranges. In children with palpable goiter, IGF-1 levels were lower and IGFBP-3 and IGFBP-1 levels were not different from the healthy control group. However, at the presence of goiter IGF-1 levels decrease. This decrease can be the result of insufficient nutrition and result in short stature and weakness than their healthy peers. © Georg Thieme Verlag KG Stuttgart, New York.
dc.identifier.DOI-ID10.1055/s-0029-1237732
dc.identifier.issn14393646
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18633
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAnthropometry
dc.subjectBody Height
dc.subjectBody Mass Index
dc.subjectBody Weight
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectGoiter
dc.subjectHumans
dc.subjectInsulin-Like Growth Factor Binding Protein 1
dc.subjectInsulin-Like Growth Factor Binding Protein 3
dc.subjectInsulin-Like Growth Factor I
dc.subjectMale
dc.subjectNutritional Status
dc.subjectRegression Analysis
dc.subjectStatistics, Nonparametric
dc.subjectThyroid Hormones
dc.subjectigfbp related protein 1
dc.subjectIGFBP related protein 3
dc.subjectliothyronine
dc.subjectsomatomedin binding protein
dc.subjectsomatomedin C
dc.subjectthyroid hormone
dc.subjectthyrotropin
dc.subjectthyroxine
dc.subjectunclassified drug
dc.subjectanthropometry
dc.subjectarticle
dc.subjectblood level
dc.subjectbody height
dc.subjectbody mass
dc.subjectbody weight
dc.subjectchild
dc.subjectcomparative study
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfree liothyronine index
dc.subjectfree thyroxine index
dc.subjectgoiter
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnutritional assessment
dc.subjectpalpation
dc.subjectpriority journal
dc.subjectpuberty
dc.subjectshort stature
dc.subjectthyroid hormone blood level
dc.subjectunderweight
dc.titleInteractions of thyroid hormones; Insulin-like growth factor-1 (IGF-1), igf binding proteins, and nutritional anthropometric parameters in school children with goiter detected by palpation
dc.typeArticle

Files

Collections

Scopus Koleksiyonu