Investigation of efficacy of treatment in spinal cord injury: Erythropoietin versus methylprednisolone

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dc.contributor.authorOzkunt O.
dc.contributor.authorSariyilmaz K.
dc.contributor.authorGemalmaz H.C.
dc.contributor.authorGürgen S.G.
dc.contributor.authorYener U.
dc.contributor.authorDikici F.
dc.date.accessioned2024-07-22T08:10:38Z
dc.date.available2024-07-22T08:10:38Z
dc.date.issued2017
dc.description.abstractBackground: Investigation of the expression of platelet-derived growth factor (PDGF)-β and glial fibrillary acidic protein (GFAP) in rats with spinal cord injury as a marker of neurologic recovery between groups treated with erythropoietin (EPO) and methylprednisolone (MP). Methods: Thirty adult female rats were randomly divided into three even groups. A laminectomy was applied to thoracic ninth vertebra and contusion injury was induced by extradural application of an aneurysm clip. Group 1 rats received one-time intrathecal administration of normal saline, group 2 rats received MP, and group 3 rats received EPO. Motor neurological function was evaluated by the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale. Thirty days after the surgery, T8–10 segments of the spinal cords were extracted and the immunohistochemical assay revealed the number of PDGF-β-and GFAP-positive cells. Results: Evaluation of the last control animal showed that BBB score in the EPO group showed an increase from 1 to 12 (p < 0.05). The immunohistochemical assay revealed that the number of PDGF-β-and GFAP-positive cells was significantly higher in EPO group (p = 0.000) when compared to MP and control groups. After studying the effect of PDGF-β expression on the locomotor function, we determined that PDGF-β expression and locomotor function after a spinal injury has a strong relationship (p < 0.05). Conclusion: EPO seems to better increase the expression of PDGF-β, thus produce better results in locomotor functions when compared to MP. © The Author(s) 2017.
dc.identifier.DOI-ID10.1177/2309499017739481
dc.identifier.issn10225536
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15321
dc.language.isoEnglish
dc.publisherSAGE Publications Ltd
dc.rightsAll Open Access; Gold Open Access
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectErythropoietin
dc.subjectFemale
dc.subjectGlial Fibrillary Acidic Protein
dc.subjectLaminectomy
dc.subjectMethylprednisolone
dc.subjectNeuroprotective Agents
dc.subjectProto-Oncogene Proteins c-sis
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectRecovery of Function
dc.subjectSpinal Cord Injuries
dc.subjectThoracic Vertebrae
dc.subjecterythropoietin
dc.subjectglial fibrillary acidic protein
dc.subjectmethylprednisolone
dc.subjectplatelet derived growth factor beta receptor
dc.subjectsodium chloride
dc.subjecterythropoietin
dc.subjectglial fibrillary acidic protein
dc.subjectmethylprednisolone
dc.subjectneuroprotective agent
dc.subjectplatelet derived growth factor B
dc.subjectadult
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectBasso Beattie and Bresnahan locomotor rating scale
dc.subjectcomparative effectiveness
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectexperimental spinal cord injury
dc.subjectfemale
dc.subjectimmunohistochemistry
dc.subjectmotor performance
dc.subjectneurologic disease assessment
dc.subjectnonhuman
dc.subjectprotein expression
dc.subjectrat
dc.subjectspinal cord injury
dc.subjectSprague Dawley rat
dc.subjectanimal
dc.subjectcomparative study
dc.subjectconvalescence
dc.subjectdisease model
dc.subjectlaminectomy
dc.subjectmetabolism
dc.subjectspinal cord injury
dc.subjectthoracic vertebra
dc.titleInvestigation of efficacy of treatment in spinal cord injury: Erythropoietin versus methylprednisolone
dc.typeArticle

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