First Report and in Silico Analysis of Leishmania virus (LRV2) identified in an autochthonous Leishmania major isolate in Turkey

Simple item page
dc.contributor.authorKurt Ö.
dc.contributor.authorMansur N.
dc.contributor.authorÇavuş I.
dc.contributor.authorÖzcan O.
dc.contributor.authorBurak Batir M.
dc.contributor.authorGündüz C.
dc.contributor.authorSezerman U.
dc.contributor.authorÖzbilgın A.
dc.date.accessioned2024-07-22T08:09:10Z
dc.date.available2024-07-22T08:09:10Z
dc.date.issued2019
dc.description.abstractLeishmania virus (LRV) has previously been identified in different Leishmania species. Host-LRV interaction is associated with exacerbated clinical manifestations of cutaneous leishmaniasis (CL) and may cause poor therapeutic response. CL cases due to L. major with large skin lesions resistant to routine therapy were recently identified in Turkey. Here, we report the first autochthonous case of cutaneous leishmaniasis caused by LRV-positive Leishmania major, using conventional PCR targeting the viral capsid protein of LRV. The lesion of the case was 6 months old, relatively large (4 cm), and did not recover despite three consecutive intralesional applications of glucantime. Assessment of LRV’s influence on prognosis and clinical outcomes of leishmaniasis, based on additional studies, is required. ©2019 by EDIMES - Edizioni Internazionali Srl. All rights reserved
dc.identifier.issn11217138
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14695
dc.language.isoEnglish
dc.publisherLuigi Ponzio e figlio Editori
dc.subjectCapsid Proteins
dc.subjectDNA Viruses
dc.subjectHumans
dc.subjectInfant
dc.subjectLeishmania major
dc.subjectLeishmaniasis, Cutaneous
dc.subjectPolymerase Chain Reaction
dc.subjectTreatment Failure
dc.subjectTurkey
dc.subjectcapsid protein
dc.subjectDNA virus
dc.subjectcase report
dc.subjectgenetics
dc.subjecthuman
dc.subjectinfant
dc.subjectisolation and purification
dc.subjectLeishmania major
dc.subjectmicrobiology
dc.subjectpathology
dc.subjectpolymerase chain reaction
dc.subjectskin leishmaniasis
dc.subjecttreatment failure
dc.subjectturkey (bird)
dc.subjectvirology
dc.titleFirst Report and in Silico Analysis of Leishmania virus (LRV2) identified in an autochthonous Leishmania major isolate in Turkey
dc.typeArticle

Files

Collections

Scopus Koleksiyonu