EVect of lisinopril on renal tissue damage in unilateral ureteral obstruction in rats

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dc.contributor.authorKarabuga Ä.
dc.contributor.authorAkbay K.
dc.contributor.authorTurna B.
dc.contributor.authorVatansever H.S.
dc.contributor.authorAltay B.
dc.contributor.authorGüzel E.
dc.contributor.authorUluer E.T.
dc.contributor.authorUstun G.
dc.contributor.authorEkren F.
dc.contributor.authorNazli O.
dc.contributor.authorMuftuoglu S.
dc.contributor.authorApaydin E.
dc.date.accessioned2024-07-22T08:19:29Z
dc.date.available2024-07-22T08:19:29Z
dc.date.issued2012
dc.description.abstractIn this study, it was aimed to investigate apoptosis in renal injury and the eVect of lisinopril in rat model, which constitute unilateral ureteral obstruction. The retroperitoneal ureter was ligated with a 4.0 silk for the experimental model of ureteral obstruction in Wistar albino rats. Untreated group (n = 20) received no treatment. For the lisinopril-treated group (n = 20), 20 mg/kg/day of drug was given orally. Ultrastructural diVerences were analyzed using electron microscopic technique; apoptotic distribution was analyzed using the TUNEL method. After electron microscopic evaluation, on the 4th and 14th day in the untreated group, edema in the glomeruli, loss of microvillus and apoptotic cells in proximal tubule cells and sclerosis in the glomeruli were detected. On the 4th day in the lisinopril-treated group, the kidney was ultrastructurally normal and a less number of apoptotic cells were only observed on the 14th day. On light microscopic examination on the 4th and 14th day in the untreated group, while the glomeruli were normal in structure, the boundary of the proximal tubule was disrupted and some picnotic cells in both the proximal and collecting tubules were observed. In both 4th and 14th day of the lisinopril-treated group, kidney showed normal structure, although in some places picnotic cells in the collecting tubules were observed. In conclusion, lisinopril was eVective and it may prevent early renal damage in the direct obstruction model. © Springer-Verlag 2011.
dc.identifier.DOI-ID10.1007/s00240-011-0393-7
dc.identifier.issn14340879
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17687
dc.language.isoEnglish
dc.subjectAngiotensin-Converting Enzyme Inhibitors
dc.subjectAnimals
dc.subjectIn Situ Nick-End Labeling
dc.subjectKidney
dc.subjectLisinopril
dc.subjectMale
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectUreteral Obstruction
dc.subjectlisinopril
dc.subjectdipeptidyl carboxypeptidase inhibitor
dc.subjectlisinopril
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectarticle
dc.subjectchemoprophylaxis
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectedema
dc.subjectglomerulosclerosis
dc.subjectkidney collecting tubule
dc.subjectkidney injury
dc.subjectkidney proximal tubule
dc.subjectkidney tubule cell
dc.subjectmale
dc.subjectmicrovillus
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectureter obstruction
dc.subjectanimal
dc.subjectkidney
dc.subjectnick end labeling
dc.subjectpathology
dc.subjectultrastructure
dc.subjectWistar rat
dc.titleEVect of lisinopril on renal tissue damage in unilateral ureteral obstruction in rats
dc.typeArticle

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