Mechanism of diabetes related to atypical antipsychotics; [Atipik antipsikotiklere baǧli geliflen diyabetin mekanizmasi]

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dc.contributor.authorYurtsever F.
dc.contributor.authorEsen-Danaci A.
dc.contributor.authorDeveci A.
dc.date.accessioned2024-07-22T08:22:56Z
dc.date.available2024-07-22T08:22:56Z
dc.date.issued2007
dc.description.abstractNew researches and case reports have revealed that diabetes incidence is higher in patients treated with new generation antipsychotics. The incidence of diabetes is 2-3 fold in schizophrenic patients compared to normal population. It is confuses that the use of new generation antipsychotics increases the risk of diabetes and cardiovascular diseases related to it. With the use of new generation antipsycotics onset age of diabetes went under 40 years in patients with schizophrenia. Even though the mechanism of diabetes caused by new generation antipsychotics is unclear some hypotheses include mechanisms related with dopamine receptor antagonism, increase in body weight, histamine 1 and 5-HT2A or 5-HT2C receptor antagonism, increase in serum leptin, insulin resistance and direct effects on pancreas. We reviewed the evidence regarding the diabetogenic effects of new generation antipsychotics and possible underlying mechanisms of this effect.
dc.identifier.issn13029657
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19293
dc.language.isoTurkish
dc.subjectclozapine
dc.subjectdopamine receptor
dc.subjectdopamine receptor blocking agent
dc.subjecthistamine H1 receptor
dc.subjectleptin
dc.subjectneuroleptic agent
dc.subjectolanzapine
dc.subjectquetiapine
dc.subjectrisperidone
dc.subjectserotonin 2A receptor
dc.subjectserotonin 2C receptor
dc.subjectarticle
dc.subjectcardiovascular disease
dc.subjectdiabetes mellitus
dc.subjecthuman
dc.subjectincidence
dc.subjectinsulin resistance
dc.subjectpathogenesis
dc.subjectrisk assessment
dc.subjectschizophrenia
dc.subjectweight gain
dc.titleMechanism of diabetes related to atypical antipsychotics; [Atipik antipsikotiklere baǧli geliflen diyabetin mekanizmasi]
dc.typeArticle

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