A comparison of the molecular distribution of proangiogenic factors in endometrium of missed abortions and of voluntary first trimester termination cases

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dc.contributor.authorÖzçakir T.
dc.contributor.authorTuran M.A.
dc.contributor.authorŞimşek F.
dc.contributor.authorAtay C.
dc.contributor.authorVatansever S.
dc.contributor.authorÖzbilgin K.
dc.date.accessioned2024-07-22T08:14:34Z
dc.date.available2024-07-22T08:14:34Z
dc.date.issued2015
dc.description.abstractObjective: The authors aimed to evaluate the angiogenic changes that occur in the cases with missed abortions compared with the voluntary termination of pregnancy as control group, with this controlled clinical study. Materials and Methods: The study included fifteen healthy volunteer women with unwanted pregnancy less than 10th gestational week in an academic research environment. The patients were 19 women between 6th and 11th gestational weeks diagnosed with missed abortion as the patient group. Immunohistochemistry was utilized to examine temporal and spatial expression of vascular endothelial growth factor (VEGF) and their two receptors: VEGF-R1 (Flt-1) and VEGF-R2 (Flk-l/KDR), and Trombospondin-1, eNOS, iNOS, and HIF-la in the both deciduas and placenta of the both groups. Results: This study discovered the significant difference (p < 0.005) between the groups of controlled and missed abortion in the decidual and placental cell components, and has put forward that thrombospondin and iNOS have an impact on abortion through antiangiogenic effect in cases of missed abortions. Conclusions: The potential role of molecules affecting angiogenesis in the etiology of missed abortion has been evaluated and the authors aimed for this to be a guide for studies on further treatments and on the prevention of the development of missed abortions.
dc.identifier.DOI-ID10.12891/ceog1774.2015
dc.identifier.issn03906663
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16611
dc.language.isoEnglish
dc.publisherS.O.G. CANADA Inc.
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAbortion, Induced
dc.subjectAbortion, Missed
dc.subjectAdult
dc.subjectDecidua
dc.subjectFemale
dc.subjectGestational Age
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectNeovascularization, Pathologic
dc.subjectNitric Oxide Synthase Type II
dc.subjectPlacenta
dc.subjectPregnancy
dc.subjectPregnancy Trimester, First
dc.subjectVascular Endothelial Growth Factor A
dc.subjectVascular Endothelial Growth Factor Receptor-1
dc.subjectangiogenic factor
dc.subjectendothelial nitric oxide synthase
dc.subjecthypoxia inducible factor 1alpha
dc.subjectinducible nitric oxide synthase
dc.subjectthrombospondin 1
dc.subjectvasculotropin
dc.subjectvasculotropin receptor 1
dc.subjectvasculotropin receptor 2
dc.subjectinducible nitric oxide synthase
dc.subjectvasculotropin A
dc.subjectvasculotropin receptor 1
dc.subjectadult
dc.subjectangiogenesis
dc.subjectantiangiogenic activity
dc.subjectArticle
dc.subjectcell component
dc.subjectclinical article
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectdecidua
dc.subjectendometrium
dc.subjectfemale
dc.subjectfirst trimester pregnancy
dc.subjectgene expression
dc.subjectgestational age
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectmissed abortion
dc.subjectnormal human
dc.subjectplacenta
dc.subjectpregnancy termination
dc.subjectprotein expression
dc.subjectunwanted pregnancy
dc.subjectAbortion, Missed
dc.subjectcomplication
dc.subjectdecidua
dc.subjectfirst trimester pregnancy
dc.subjectinduced abortion
dc.subjectmetabolism
dc.subjectNeovascularization, Pathologic
dc.subjectpathology
dc.subjectphysiology
dc.subjectplacenta
dc.subjectpregnancy
dc.titleA comparison of the molecular distribution of proangiogenic factors in endometrium of missed abortions and of voluntary first trimester termination cases
dc.typeArticle

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