N-acetylcysteine prevents gentamicin ototoxicity in a rat model

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dc.contributor.authorSomdaş M.A.
dc.contributor.authorKorkmaz F.
dc.contributor.authorGurgen S.G.
dc.contributor.authorSagit M.
dc.contributor.authorAkcadağ A.
dc.date.accessioned2024-07-22T08:14:18Z
dc.date.available2024-07-22T08:14:18Z
dc.date.issued2015
dc.description.abstractOBJECTIVE: The possible preventive effect of N-acetylcysteine (NAC) in gentamicin ototoxicity was studied with auditory brain stem responses (ABRs), otoacoustic emissions (OAEs), and histopathological investigation of the cochlea. MATERIALS and METHODS: This study is conducted on 36 rats in three groups. Gentamicin, gentamicin plus NAC, and NAC alone were intraperitoneally administered for 15 days. The rats were sacrificed to study the cochleas after testing hearing levels. RESULTS: ABR thresholds and OAEs were attenuated in the gentamicin group, in which apoptosis was detected with histopathological investigation. The group that received NAC in addition to gentamicin had better ABR thresholds and better OAEs. The histopathological evidence of apoptosis in was considerably less in this group. CONCLUSION: Gentamicin ototoxicity can be detected by ABR and OAE testing in rats, and NAC may protect the cochlear cells from apoptosis. © The Mediterranean Society of Otology and Audiology.
dc.identifier.DOI-ID10.5152/iao.2015.650
dc.identifier.issn13087649
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16549
dc.language.isoEnglish
dc.publisherMediterranean Society of Otology and Audiology
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAcetylcysteine
dc.subjectAnimals
dc.subjectCochlea
dc.subjectDisease Models, Animal
dc.subjectEar Diseases
dc.subjectEvoked Potentials, Auditory, Brain Stem
dc.subjectFemale
dc.subjectFree Radical Scavengers
dc.subjectGentamicins
dc.subjectOtoacoustic Emissions, Spontaneous
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectRats, Wistar
dc.subjectacetylcysteine
dc.subjectgentamicin
dc.subjectscavenger
dc.subjectanimal
dc.subjectchemically induced
dc.subjectcochlea
dc.subjectdisease model
dc.subjectdrug effects
dc.subjectEar Diseases
dc.subjectevoked brain stem auditory response
dc.subjectfemale
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectrat
dc.subjectspontaneous otoacoustic emission
dc.subjectSprague Dawley rat
dc.subjectWistar rat
dc.titleN-acetylcysteine prevents gentamicin ototoxicity in a rat model
dc.typeArticle

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