The Effect of N-Acetylcysteine on the Neurofilament and Nerve Growth Factor Expression after Gentamicin Induced Cochlear Damage
| dc.contributor.author | Sarsmaz, HY | |
| dc.contributor.author | Gürgen, SG | |
| dc.contributor.author | Somdas, MA | |
| dc.date.accessioned | 2025-04-10T10:31:47Z | |
| dc.date.available | 2025-04-10T10:31:47Z | |
| dc.description.abstract | Objective: To investigate of the effectiveness of N-acetylcysteine (NAC) in preventing cochlear damage due to gentamicin by the means of expression of neuronal factors Metods: In our study, 36 female Spraguea Dawley rats were used. They were divided into 3 groups such as (saline), Gentamicin + Serum physiological (saline) and Gentamicin + NAC. After 15 days, the rats were sacrificed. Cochleae were removed and examined histopathologically. The immunoreactivity of neurofilament and neuronal growth factor primary antibodies was examined in the tissues taken. Results: Neuroflament immunoreactivity was quite significant in afferent and efferent nerve bundles in the saline group and Gentamicin + NAC group, whereas it was weak in the Gentamicin + serum physiological group. Also neuronal growth factor immunoreactivity was moderate in afferent and efferent nerve bundles in the saline group and Gentamicin + NAC group, it was negative at vestibular ganglia, and weak in afferent and efferent nerve fiber bundles in the Gentamicin + serum physiological group. Conclusion: It was shown immunohistochemically that ototoxicity caused by gentamicin was significantly reduced when the NAC combination was applied. | |
| dc.identifier.issn | 2147-2092 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/38256 | |
| dc.language.iso | Turkish | |
| dc.title | The Effect of N-Acetylcysteine on the Neurofilament and Nerve Growth Factor Expression after Gentamicin Induced Cochlear Damage | |
| dc.type | Article |