The effect of beta-blocking agents on morbidity und mortality following coronary artery bypass surgery; [Kronik beta bloker kullaniminin koroner baypas cerrahisi sonrasi morbidite ve mortalite üzerine etkileri]
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2013
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Objective: Aim of this study was to investigate the effect of beta-blocking agents on both short and long-term morbidity and mortality in patients undergoing coronary artery bypass surgery. Material and Methods: Between January 2010 and March 2012, the patients undergoing coronary artery bypass surgery in our cardiovascular surgery clinic were divided into two groups; Group B included the patients who had (Group B) or had not (Group C) been using beta-blocking agents preoperatively, Demographic and clinical characteristics, intraoperative and postoperative clinical parameters as well as short (30-days) and long-term (1 year) rates of morbidity and mortality were retrospectively evaluated. Results: Number of patients with atrial fibrillation was significantly lower in Group B (n=17, 20% vs. n=28, 35%; p<0.01). Frequency of agitation-delirium in Group B was also significantly less than Group C (n=2, 3% vs. n=8, 10%; p=0.05). Thirty-day morbidity was also higher in Group C than Group B (n=28, 35% vs. n=17, 20%; p<0.04), however this difference disappeared after 1 year (n=30 38% vs. n=24, 28%; p=0.2). Neither 30-day nor 1 year-mortality rates were statistically significant between Groups B and C (p=0.4 and p=0.2, respectively). Conclusion: Compared to the control group, the frequencies of both atrial fibrillation and agitation-delirium were significantly lower in Group B in this cohort of patients. The long term use of beta-blocking agents prior to coronary artery bypass surgery appears to markedly reduce 30-day morbidity, despite this effect was not reflected on short and long-term mortality rates.