Comparison of the efficacy of combination and monotherapy with caspofungin and liposomal amphotericin B against invasive candidiasis

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dc.contributor.authorTunger O.
dc.contributor.authorBayram H.
dc.contributor.authorDegerli K.
dc.contributor.authorDinc G.
dc.contributor.authorCetin B.C.
dc.date.accessioned2024-07-22T08:22:18Z
dc.date.available2024-07-22T08:22:18Z
dc.date.issued2008
dc.description.abstractObjective: To investigate if combination therapy with liposomal amphotericin B (LAmB), and caspofungin (CAS) is superior to monotherapies in an experimental model with azole-resistant Candida albicans. Methods: This study was carried out between October 2006 and August 2007 in Celal Bayar University, Manisa, Turkey. A total of 144 mice were included in the study, and divided into 4 groups as: control (n=36), CAS treatment group (n=36), LAmB treatment group (n=36), and combination therapy group (n=36). Treatment efficacy was assessed by determining survival, as well as, the decrease in tissue fungal densities. Results: The fungal densities in tissues were significantly reduced, and the survival rates were prolonged with either CAS only, or LAmB only, or with combination therapy compared to those of controls (p<0.05). There was no significant difference between monotherapy groups. Decrease in tissue fungal densities were significant in CAS and LAmB (1mg/kg) combination group, compared to CAS (1mg/kg) and LAmB (1mg/kg) groups (p=0.004 for CAS, p=0.009 for LAmB). Survival rates were similar in both treatment groups. Conclusion: The combination treatment was superior with 1mg/kg of doses of LAmB and CAS in terms of reducing the tissue fungal burden. Although with combination therapy the survival rates prolonged in all subgroups, no significant difference between the combination and monotherapies could be shown. Additional studies with a large number of cases are warranted to investigate the superiority of combination therapy.
dc.identifier.issn16583175
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19018
dc.language.isoEnglish
dc.subjectAmphotericin B
dc.subjectAnimals
dc.subjectCandidiasis
dc.subjectDrug Therapy, Combination
dc.subjectEchinocandins
dc.subjectMice
dc.subjectStatistics, Nonparametric
dc.subjectSurvival Rate
dc.subjectamphotericin B lipid complex
dc.subjectcaspofungin
dc.subjectfluconazole
dc.subjectamphotericin B
dc.subjectamphotericin B lipid complex
dc.subjectcaspofungin
dc.subjectechinocandin
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantifungal susceptibility
dc.subjectarticle
dc.subjectCandida albicans
dc.subjectcombination chemotherapy
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectdrug response
dc.subjectinvasive candidiasis
dc.subjectmale
dc.subjectmonotherapy
dc.subjectmouse
dc.subjectnonhuman
dc.subjectsurvival rate
dc.subjectTurkey (republic)
dc.subjectanimal
dc.subjectcandidiasis
dc.subjectcomparative study
dc.subjectdrug combination
dc.subjectnonparametric test
dc.titleComparison of the efficacy of combination and monotherapy with caspofungin and liposomal amphotericin B against invasive candidiasis
dc.typeArticle

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