Diagnostic value of stool antigen and antibody tests for Helicobacter pylori infection in Turkish children with upper gastrointestinal complaints before and after eradication

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dc.contributor.authorTiryaki Z.
dc.contributor.authorYilmaz-Çiftdoǧan D.
dc.contributor.authorKasirga E.
dc.date.accessioned2024-07-22T08:20:34Z
dc.date.available2024-07-22T08:20:34Z
dc.date.issued2010
dc.description.abstractThe aim of this study was to evaluate the diagnostic value of Helicobacter pylori stool antigen (HpSA) and serologic tests before and after eradication therapy for H. pylori in Turkish children in our region with upper gastrointestinal complaints. In this study, 87 children with upper gastrointestinal complaints and 95 children with various symptoms without gastrointestinal complaints were enrolled. H. pylori infection was detected by urea breath test (UBT). HpSA and H. pylori immunoglobulin G (HpIgG) tests were applied to all the children. Eradication treatment was given to the 34 H.pyfon'-positive children. The UBT was positive in 43 of 87 children (49.4%) with upper gastrointestinal complaints. The sensitivity and specificity of the HpSA in children with upper gastrointestinal complaints were 86% and 84.1%, respectively, and those for the HpIgG were 76.7% and 90.9%, respectively. After eradication, the overall HpSA test sensitivity and specificity values were detected as 88.9% and 84%, respectively, and those for the HpIgG were 77.8% and 36%, respectively. The HpSA test is highly sensitive and specific for the diagnosis of H. pylori and for confirming eradication in Turkish children with upper gastrointestinal complaints. However, serology is not a reliable method for the diagnosis of H. pylori infection or for confirming eradication in children.
dc.identifier.issn00414301
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18224
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAge Factors
dc.subjectAntibodies, Monoclonal
dc.subjectAntigens, Bacterial
dc.subjectChild
dc.subjectDrug Monitoring
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFeces
dc.subjectFemale
dc.subjectHelicobacter Infections
dc.subjectHelicobacter pylori
dc.subjectHumans
dc.subjectImmunoglobulin G
dc.subjectMale
dc.subjectSensitivity and Specificity
dc.subjectSerologic Tests
dc.subjectTurkey
dc.subjectamoxicillin
dc.subjectclarithromycin
dc.subjectimmunoglobulin G
dc.subjectlansoprazole
dc.subjectadolescent
dc.subjectadult
dc.subjectarticle
dc.subjectchild
dc.subjectcontrolled study
dc.subjectdiagnostic accuracy
dc.subjectdiagnostic test
dc.subjectdiagnostic test accuracy study
dc.subjectdiagnostic value
dc.subjectgastrointestinal symptom
dc.subjectHelicobacter infection
dc.subjectHelicobacter pylori stool antigen test
dc.subjecthuman
dc.subjectinfection control
dc.subjectmajor clinical study
dc.subjectpreschool child
dc.subjectschool child
dc.subjectsensitivity and specificity
dc.subjectserology
dc.subjectTurkey (republic)
dc.subjectupper gastrointestinal tract
dc.subjecturea breath test
dc.titleDiagnostic value of stool antigen and antibody tests for Helicobacter pylori infection in Turkish children with upper gastrointestinal complaints before and after eradication
dc.typeArticle

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