Selected transient receptor potential channel genes’ expression in peripheral blood mononuclear cells of multiple sclerosis

Simple item page
dc.contributor.authorÇakır M.
dc.contributor.authorSaçmacı H.
dc.contributor.authorSabah-Özcan S.
dc.date.accessioned2024-07-22T08:05:27Z
dc.date.available2024-07-22T08:05:27Z
dc.date.issued2021
dc.description.abstractTransient receptor potential channels have responsibilities in many cellular processes such as cytokine production, cell differentiation, and cytotoxicity by affecting intracellular cation levels or intracellular signal pathways. Multiple sclerosis is a chronic autoimmune central nervous system (CNS) disease caused by environmental and genetic factors. In this study, we aim to investigate TRPV1-TRPV4, TRPM2, TRPM4, TRPM7, TRPC6, and TRPA1 mRNA expression levels, which are associated with the inflammatory process, in the peripheral blood mononuclear cells (PBMCs) of relapsing-remitting multiple sclerosis (RRMS) patients. Thirty-five healthy controls and age–gender matched thirty patients with RRMS were involved in the study. TRPC6, TRPA1, TRPM2, TRPM4, TRPM7, TRPV1, TRPV2, TRPV3, and TRPV4 PBMCs mRNA expression levels were determined by qPCR. In the present study, the TRPC6, TRPM7, TRPV1, TRPV3, and TRPV4 mRNA expressions of RRMS patients in PBMCs decreased at a significant level compared to the healthy control group (p =.000, p =.000, p =.044, p =.000, p =.004, respectively). The decreased expression of TRPC6, TRPM7, TRPV1, TRPV3, and TRPV4 in PBMCs may be associated with the pathogenesis of MS. Further studies are required to understand the mechanism of the relation between these TRP channels and MS and other autoimmune diseases. © The Author(s) 2021.
dc.identifier.DOI-ID10.1177/09603271211043476
dc.identifier.issn09603271
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13146
dc.language.isoEnglish
dc.publisherSAGE Publications Ltd
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectGene Expression Regulation
dc.subjectHumans
dc.subjectLeukocytes, Mononuclear
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectTransient Receptor Potential Channels
dc.subjectYoung Adult
dc.subjectmessenger RNA
dc.subjecttransient receptor potential channel 6
dc.subjecttransient receptor potential channel M7
dc.subjectvanilloid receptor 1
dc.subjectvanilloid receptor 3
dc.subjectvanilloid receptor 4
dc.subjecttransient receptor potential channel
dc.subjectadult
dc.subjectArticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectfemale
dc.subjectgender
dc.subjectgene
dc.subjectgene expression
dc.subjecthuman
dc.subjectmale
dc.subjectmultiple sclerosis
dc.subjectpathogenesis
dc.subjectperipheral blood mononuclear cell
dc.subjectpolymerase chain reaction
dc.subjectprotein expression
dc.subjectTRP gene
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectmononuclear cell
dc.subjectyoung adult
dc.titleSelected transient receptor potential channel genes’ expression in peripheral blood mononuclear cells of multiple sclerosis
dc.typeArticle

Files

Collections

Scopus Koleksiyonu