Synthesis and antimicrobial evaluation of sulfanilamide- and carbohydrate-derived 1,4-disubstitued-1,2,3-triazoles via click chemistry

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dc.contributor.authorAy K.
dc.contributor.authorIspartaloğlu B.
dc.contributor.authorHalay E.
dc.contributor.authorAy E.
dc.contributor.authorYaşa İ.
dc.contributor.authorKarayıldırım T.
dc.date.accessioned2024-07-22T08:10:41Z
dc.date.available2024-07-22T08:10:41Z
dc.date.issued2017
dc.description.abstract4-Sulfanilamido substitued-1,2,3-triazoles conjugated with monosaccharides (8–17) including d-glucose, d-galactose, d-mannose, and d-fructose were synthesized in good yields from azidosugars with propargyl sulfanilamides using copper catalyst 1,3-dipolar cycloaddition reaction (CuAAC). The structures of new compounds were elucidated by liquid chromatography-mass spectrometry, infrared, one-dimensional- and two-dimensional-nuclear magnetic resonance techniques. All of the new compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeruginosa, and Candida albicans for their antibacterial and antifungal activities. Experimental results showed antimicrobial activity with minimum inhibitory concentrations values a ranging from 0.078 to 5.0 mg/mL against test microorganisms. © 2017, Springer Science+Business Media New York.
dc.identifier.DOI-ID10.1007/s00044-017-1864-3
dc.identifier.issn10542523
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15344
dc.language.isoEnglish
dc.publisherBirkhauser Boston
dc.subject1,2,3 triazole derivative
dc.subject4 ({[4' acetamidobenzenesulfonyl]amino}methyl) 1 (2",3",4",6" di o acetyl beta dextro mannofuranosyl) 1h 1,2,3 triazole
dc.subject4 ({[4' acetamidobenzenesulfonyl]amino}methyl) 1 (2",3",4",6" di o isopropylidene beta dextro fructopyranosyl) 1h 1,2,3 triazole
dc.subject4 ({[4' acetamidobenzenesulfonyl]amino}methyl) 1 (2",3",4",6" tetra o acetyl beta dextro galactopyranosyl) 1h 1,2,3 triazole
dc.subject4 ({[4' acetamidobenzenesulfonyl]amino}methyl) 1 (2",3",4",6" tetra o acetyl beta dextro glucopyranosyl) 1h 1,2,3 triazole
dc.subject4 ({[4' acetamidobenzenesulfonyl]amino}methyl) 1 (6'' deoxy 1",2"
dc.subject3",4" di o isopropylidene alpha dextro galactopyranose 6" yl) 1h 1,2,3 triazole
dc.subjectantibiotic agent
dc.subjectantifungal agent
dc.subjectcarbohydrate derivative
dc.subjectsulfanilamide derivative
dc.subjectunclassified drug
dc.subjectantibacterial activity
dc.subjectantifungal activity
dc.subjectArticle
dc.subjectBacillus subtilis
dc.subjectCandida albicans
dc.subjectcontrolled study
dc.subjectdrug screening
dc.subjectdrug synthesis
dc.subjectEnterococcus faecalis
dc.subjectEscherichia coli
dc.subjectin vitro study
dc.subjectKlebsiella pneumoniae
dc.subjectliquid chromatography-mass spectrometry
dc.subjectmelting point
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectnuclear Overhauser effect
dc.subjectproton nuclear magnetic resonance
dc.subjectPseudomonas aeruginosa
dc.subjectSalmonella enterica serovar Typhimurium
dc.subjectStaphylococcus aureus
dc.titleSynthesis and antimicrobial evaluation of sulfanilamide- and carbohydrate-derived 1,4-disubstitued-1,2,3-triazoles via click chemistry
dc.typeArticle

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