Effects of cilazapril on endothelial function and pulmonary hypertension in patients with congestive heart failure.
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Date
2002
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Abstract
Flow-mediated vasodilation (FMV), brachial artery flow (BAF), and brachial artery diameter were evaluated in 30 patients with congestive heart failure before and after cilazapril treatment. While mean pulmonary artery pressure and pulmonary capillary wedge pressure decreased significantly, flow-mediated vasodilation and left ventricular ejection fraction increased significantly following cilazapril administration (P < 0.001). Brachial artery diameter and brachial artery flow did not change following the treatment period (P > 0.05). In conclusion, short-term cilazapril administration improved endothelial function and pulmonary pressure in patients with congestive heart failure.
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Keywords
Aged , Angiotensin-Converting Enzyme Inhibitors , Blood Circulation , Brachial Artery , Cilazapril , Coronary Disease , Endothelium, Vascular , Female , Heart Failure, Congestive , Humans , Hypertension, Pulmonary , Male , Middle Aged , Vasodilation , cilazapril , dipeptidyl carboxypeptidase inhibitor , aged , article , brachial artery , circulation , congestive heart failure , coronary artery disease , drug effect , female , human , male , middle aged , pathophysiology , physiology , pulmonary hypertension , vascular endothelium , vasodilatation