Could the Inflammatory Prognostic Index Predict the Efficacy of Regorafenib in Patients with Metastatic Colorectal Cancer?
No Thumbnail Available
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Purpose: To investigate the clinical importance of the inflammatory prognostic index (IPI) in patients with metastatic colorectal cancer treated with regorafenib. Methods: A retrospective analysis of 65 metastatic CRC patients treated with regorafenib between 2015 and 2020 was performed. The association between NLR, PNLR, IPI, and overall survival (OS) and progression-free survival (PFS) was evaluated. Results: According to the cut-off points, patients were divided into two groups. The patients in the high IPI group showed poorer OS compared to patients in the low IPI groups. The PFS was better in patients with low neutrophil-lymphocyte ratio (NLR) and platelet-neutrophil to lymphocyte ratio (PNLR), and the OS was better in patients with low IPI. Conclusion: Among the immune inflammation scores analyzed in mCRC patients receiving regorafenib, NLR and PNLR were the best predictor of recurrence, whereas IPI was the best predictor of long-term survival. After being confirmed by better designed controlled trials, IPI can be used to identify the group of patients who will benefit more from regorafenib treatment. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.
Description
Keywords
Colorectal Neoplasms , Humans , Phenylurea Compounds , Prognosis , Pyridines , Retrospective Studies , Survival Rate , regorafenib , carbanilamide derivative , pyridine derivative , regorafenib , Article , cancer patient , cancer recurrence , clinical evaluation , controlled study , drug efficacy , female , human , Inflammatory Prognostic Index , leukocyte parameters , long term survival , major clinical study , male , metastatic colorectal cancer , multicenter study , neutrophil lymphocyte ratio , overall survival , platelet neutrophil to lymphocyte ratio , prediction , prognostic assessment , progression free survival , retrospective study , colorectal tumor , pathology , prognosis , survival rate