Metabolic syndrome and carotid intima-media thickness in chronic obstructive pulmonary disease

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dc.contributor.authorAlpaydin A.O.
dc.contributor.authorArslan I.K.
dc.contributor.authorSerter S.
dc.contributor.authorCoskun A.S.
dc.contributor.authorCelik P.
dc.contributor.authorTaneli F.
dc.contributor.authorYorgancioglu A.
dc.date.accessioned2024-07-22T08:18:16Z
dc.date.available2024-07-22T08:18:16Z
dc.date.issued2013
dc.description.abstractBackground: The aim of this study is to investigate the prevalence of metabolic syndrome (MetS), carotid intima media thickness (IMT), and serum C-reactive protein (CRP) levels in patients with chronic obstructive pulmonary disease (COPD), and the possible relationships among them. Methods: Fifty stable COPD patients and 40 healthy controls were included in the study. The participants were further divided into four groups according to their smoking status. Pulmonary function tests were performed in COPD patients. Anthropometric measurements and blood chemistry analysis, serum CRP levels and carotid intimamedia thickness (IMT) measurements were performed in all the study population. Results: Prevalence of metabolic syndrome was 43% in COPD patients and 30% in the control group (p = 0.173). FEV1% and FEV 1/FVC were higher in COPD patients with MetS (p = 0.001 and p = 0.014, respectively) compared to those without MetS. Prevalence of MetS was significantly different among the COPD patients with different stages (p = 0.017) with the highest value in stage 2 (59%). Carotid IMT was significantly higher in COPD patients than in control group (1.07 ± 0.25 mm and 0.86 ± 0.18 mm, respectively; p < 0.001). Serum CRP levels were not different in COPD patients and controls, however they were higher in individuals with MetS compared to those without MetS regardless of COPD presence (p = 0.02). Conclusions: Early markers of atherogenesis, in terms of carotid IMT, were found to be higher in COPD patients than in healthy controls. MetS prevalence was observed to decrease as the severity of airflow obstruction increased. Therefore, screening COPD patients for these cardiovascular risk factors would be a novel approach even in absence of symptoms. © 2013 Ozgen Alpaydin et al.
dc.identifier.DOI-ID10.1186/2049-6958-8-61
dc.identifier.issn1828695X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17256
dc.language.isoEnglish
dc.publisherBioMed Central Ltd.
dc.rightsAll Open Access; Gold Open Access
dc.subjectC reactive protein
dc.subjectadult
dc.subjectaged
dc.subjectarterial wall thickness
dc.subjectarticle
dc.subjectblood chemistry
dc.subjectcarotid atherosclerosis
dc.subjectchronic obstructive lung disease
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectforced expiratory volume
dc.subjectforced vital capacity
dc.subjecthuman
dc.subjectlung function test
dc.subjectmale
dc.subjectmetabolic syndrome X
dc.subjectsmoking
dc.titleMetabolic syndrome and carotid intima-media thickness in chronic obstructive pulmonary disease
dc.typeArticle

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