Exenatide improves ovarian and endometrial injury and preserves ovarian reserve in streptozocin induced diabetic rats

Simple item page
dc.contributor.authorArtunc-Ulkumen B.
dc.contributor.authorPala H.G.
dc.contributor.authorPala E.E.
dc.contributor.authorYavasoglu A.
dc.contributor.authorYigitturk G.
dc.contributor.authorErbas O.
dc.date.accessioned2024-07-22T08:13:44Z
dc.date.available2024-07-22T08:13:44Z
dc.date.issued2015
dc.description.abstractWe aimed to evaluate: (1) endometrial and ovarian tissue injury caused by the glucose toxicity in diabetic rat model and (2) the effect of GLP-1 analog (exenatide) on endometrial and ovarian diabetes induced injury with emphasizing the underlying mechanism. The study group composed of 24 female rats assigned randomly into 3 groups. Group 1 was the control group (n=8) and received no treatment. Diabetes was induced by intraperitoneal injection of streptozocin for 16 rats which are further assigned randomly into 2 groups: 1ml/kg intraperitoneal saline was given to Group-2 (diabetic non-treated control group, 8 rats) and 10μg/kg/day of intraperitoneal exenatide was given to Group 3 (exenatide treated group, 8 rats) for four weeks. After four weeks, blood samples were collected and hysterectomy with bilateral oophorectomy was performed for histopathological examination. Diabetes caused endometrial and ovarian tissue injury in rats (p<0.0001). Serum transforming growth factor beta (TGF-ß), malonylaldehyde (MDA), pentraxin-3 (PTX-3) levels were higher in diabetic rats (p<0.0001), whereas antimullerian hormone (AMH) was lower (p<0.001). Serum levels of these markers reflected that Diabetes induced injury in the reproductive tract occured via oxidative stress, fibrosis and severe inflammation. Diabetes diminished ovarian reserve. Exenatide treatment improved the histological degeneration and fibrosis in the endometrium and ovary with concomitant decrease in inflammatory and oxidative stress markers (p<0.05). Exenatide also improved ovarian reserve (p<0.05). Glucose toxicity occured severely in ovary and endometrium in DM. After exenatide treatment; ovarian and endometrial injury and fibrosis seems to decrease significantly. The effects of exenatide in rat models give hope to prevent the women with DM from premature ovarian failure and endometrial dysfunction. © 2014 Informa UK Ltd.
dc.identifier.DOI-ID10.3109/09513590.2014.975686
dc.identifier.issn09513590
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16381
dc.language.isoEnglish
dc.publisherInforma Healthcare
dc.subjectAnimals
dc.subjectAnti-Mullerian Hormone
dc.subjectC-Reactive Protein
dc.subjectDiabetes Mellitus, Experimental
dc.subjectEndometrium
dc.subjectFemale
dc.subjectInflammation
dc.subjectLipid Peroxidation
dc.subjectMalondialdehyde
dc.subjectOvarian Reserve
dc.subjectOvary
dc.subjectOxidative Stress
dc.subjectPeptides
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSerum Amyloid P-Component
dc.subjectTransforming Growth Factor beta
dc.subjectVenoms
dc.subjectexendin 4
dc.subjectmalonaldehyde
dc.subjectMuellerian inhibiting factor
dc.subjectpentraxin 3
dc.subjectsodium chloride
dc.subjectstreptozocin
dc.subjecttransforming growth factor beta
dc.subjectC reactive protein
dc.subjectexendin 4
dc.subjectmalonaldehyde
dc.subjectMuellerian inhibiting factor
dc.subjectpentraxin 3
dc.subjectpeptide
dc.subjectserum amyloid P
dc.subjecttransforming growth factor beta
dc.subjectvenom
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectblood sampling
dc.subjectcontrolled study
dc.subjectdrug mechanism
dc.subjectendometrial disease
dc.subjectendometrial injury
dc.subjectfemale
dc.subjectfibrosis
dc.subjectgenital system
dc.subjectglucotoxicity
dc.subjecthistopathology
dc.subjecthysterectomy
dc.subjectinflammation
dc.subjectnonhuman
dc.subjectovarian injury
dc.subjectovarian reserve
dc.subjectovariectomy
dc.subjectovary disease
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectrat
dc.subjectstreptozotocin-induced diabetes mellitus
dc.subjecttissue injury
dc.subjectanimal
dc.subjectblood
dc.subjectdrug effects
dc.subjectendometrium
dc.subjectexperimental diabetes mellitus
dc.subjectlipid peroxidation
dc.subjectmetabolism
dc.subjectovarian reserve
dc.subjectovary
dc.subjectpathology
dc.subjectSprague Dawley rat
dc.titleExenatide improves ovarian and endometrial injury and preserves ovarian reserve in streptozocin induced diabetic rats
dc.typeArticle

Files

Collections

Scopus Koleksiyonu