Effects of levosimendan and dobutamine on experimental acute lung injury in rats

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dc.contributor.authorErbüyün K.
dc.contributor.authorVatansever S.
dc.contributor.authorTok D.
dc.contributor.authorOk G.
dc.contributor.authorTürköz E.
dc.contributor.authorAydede H.
dc.contributor.authorErhan Y.
dc.contributor.authorTekin I.
dc.date.accessioned2024-07-22T08:21:36Z
dc.date.available2024-07-22T08:21:36Z
dc.date.issued2009
dc.description.abstractThe effects of levosimendan on acute lung injury induced by peritonitis and abdominal hypertension in the early stages of sepsis in rats were investigated. Twenty-four adult male Wistar rats were randomized into: (1) sham, (2) subjected to abdominal hypertension and peritonitis induced lung injury using cecal ligation and puncture, then treated by dobutamine, (3) subjected to abdominal hypertension and peritonitis induced lung injury using cecal ligation and puncture, then treated by levosimendan, and (4) controls subjected to abdominal hypertension and peritonitis induced lung injury using cecal ligation and puncture with no treatment. In the control and levosimendan groups, cecal ligation and puncture resulted in moderate IL-1β immunolabelling in lung tissue; marked IL-1β immunolabelling was demonstrated in the dobutamine group. TNF-α immunolabelling was negative in both the sham and levosimendan groups, but moderate and weak immunoreactivities were observed in the dobutamine and control groups, respectively. There were almost no TUNEL positive cells in the sham, but they were prominent in the control. TUNEL positive cells were significantly less in the levosimendan treated lungs when compared to control and dobutamine groups. Immunoreactivity of eNOS was stronger in the dobutamine group when compared with the levosimendan group. In addition, iNOS immunoreactivity was strongly detected in the control group; this immunoreactivity was less in the levosimendan group than the dobutamine group. In this experimental sepsis model, treatment with levosimendan had a marked effect on attenuating or decreasing apoptosis and inflammation in the lung. © 2008 Elsevier GmbH. All rights reserved.
dc.identifier.DOI-ID10.1016/j.acthis.2008.09.010
dc.identifier.issn16180372
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18676
dc.language.isoEnglish
dc.subjectAcute Lung Injury
dc.subjectAnimals
dc.subjectCardiotonic Agents
dc.subjectDobutamine
dc.subjectHydrazones
dc.subjectHypertension
dc.subjectImmunohistochemistry
dc.subjectIn Situ Nick-End Labeling
dc.subjectInterleukin-1beta
dc.subjectLung
dc.subjectMale
dc.subjectNitric Oxide Synthase Type II
dc.subjectNitric Oxide Synthase Type III
dc.subjectPyridazines
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTumor Necrosis Factor-alpha
dc.subjectRattus
dc.subjectRattus norvegicus
dc.subjectdobutamine
dc.subjectendothelial nitric oxide synthase
dc.subjectinterleukin 1beta
dc.subjectlevosimendan
dc.subjecttumor necrosis factor alpha
dc.subjectacute lung injury
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantibody labeling
dc.subjectapoptosis
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectexperimental study
dc.subjecthistopathology
dc.subjectimmunoreactivity
dc.subjectmale
dc.subjectnick end labeling
dc.subjectnonhuman
dc.subjectperitonitis
dc.subjectrat
dc.titleEffects of levosimendan and dobutamine on experimental acute lung injury in rats
dc.typeArticle

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