Investigation of Cytotoxic and Antileishmanial Activity of Hybrid Silver Nanoparticle Complexes: Potential Drug Candidates against Leishmania Species; [Hibrit Gümüş Nanoparçacik Komplekslerinin Sitotoksik ve Antilayşmanyal Aktivitesinin Araştirilmasi: Leishmania Türlerine Karşi Potansiyel Ilaç Adaylari]

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dc.contributor.authorÖzel Y.
dc.contributor.authorÇavuş I.
dc.contributor.authorYilmaz U.
dc.contributor.authorTokay F.
dc.contributor.authorBaǧdat S.
dc.contributor.authorÖzbilgin A.
dc.contributor.authorÜnlü M.
dc.contributor.authorÜnlü G.V.
dc.date.accessioned2024-07-22T08:01:23Z
dc.date.available2024-07-22T08:01:23Z
dc.date.issued2024
dc.description.abstractIn recent years, isolation of resistant Leishmania species to drugs in use has made it necessary to search alternative molecules that may be drug candidates. In this study, it was aimed to investigate the cytotoxic and in vitro antileishmanial activity of hybrid silver nanoparticle (AgNP) complexes. In this study, three types of nanoparticles (NPs), oxidized amylose-silver (OA-Ag) NPs, oxidized amylose-curcumin (OA-Cur) NPs and oxidized amylose-curcumin-silver (OA-CurAgNP) nanoparticles were synthesized. The cytotoxic activity of the synthesized nanoparticles was determined against L929 mouse fibroblasts and the in vitro antileishmanial activity was determined against Leishmania tropica, Leishmania infantum and Leishmania donovani isolates by the broth microdilution method. It was observed that the hybrid OA-CurAgNP complex obtained by combining curcumin and silver nanoparticles showed cytotoxic effects against L929 mouse fibroblasts at concentrations of 1074 μg/mL and above. IC50 values expressing the antileishmanial activity of the hybrid OA-CurAgNP complex against L.tropica, L.infantum and L.donovani isolates, were found to vary between 95-121 μg/mL, 202-330 μg/mL and 210-254 μg/mL, respectively. Resistance development has emerged as a major challenge in the treatment of leishmaniasis in recent times. Metallic nanoparticles are considered excellent candidates for medical applications due to their chemical and physical properties, as well as their prolonged circulation in the body. The current drugs used for leishmaniasis treatment are highly toxic, while nanoparticles offer advantages such as low toxicity and easy cellular uptake due to their nanoscale dimensions. The identification of strong efficacy in these particles may contribute scientific evidence for their potential use in leishmaniasis treatment. Therefore, the therapeutical value of OA-CurAgNP complex alone in combination with existing drugs should be examined. © 2024 Ankara Microbiology Society. All rights reserved.
dc.identifier.DOI-ID10.5578/mb.202498184
dc.identifier.issn03749096
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11432
dc.language.isoTurkish
dc.publisherAnkara Microbiology Society
dc.subjectAnimals
dc.subjectAntiprotozoal Agents
dc.subjectCell Line
dc.subjectCurcumin
dc.subjectFibroblasts
dc.subjectInhibitory Concentration 50
dc.subjectLeishmania donovani
dc.subjectLeishmania infantum
dc.subjectLeishmania tropica
dc.subjectMetal Nanoparticles
dc.subjectMice
dc.subjectSilver
dc.subjectantiprotozoal agent
dc.subjectcurcumin
dc.subjectmetal nanoparticle
dc.subjectsilver
dc.subjectanimal
dc.subjectcell line
dc.subjectchemistry
dc.subjectdrug effect
dc.subjectfibroblast
dc.subjectIC50
dc.subjectLeishmania donovani
dc.subjectLeishmania infantum
dc.subjectLeishmania tropica
dc.subjectmouse
dc.titleInvestigation of Cytotoxic and Antileishmanial Activity of Hybrid Silver Nanoparticle Complexes: Potential Drug Candidates against Leishmania Species; [Hibrit Gümüş Nanoparçacik Komplekslerinin Sitotoksik ve Antilayşmanyal Aktivitesinin Araştirilmasi: Leishmania Türlerine Karşi Potansiyel Ilaç Adaylari]
dc.typeArticle

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