Effectiveness of quercetin in an experimental rat model of allergic rhinitis

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dc.contributor.authorSagit M.
dc.contributor.authorPolat H.
dc.contributor.authorGurgen S.G.
dc.contributor.authorBerk E.
dc.contributor.authorGuler S.
dc.contributor.authorYasar M.
dc.date.accessioned2024-07-22T08:10:36Z
dc.date.available2024-07-22T08:10:36Z
dc.date.issued2017
dc.description.abstractWe aimed to investigate whether quercetin had a therapeutic effect in an experimental rat model of allergic rhinitis. The study was conducted with 35 rats, which were randomly assigned into 4 groups: group 1 (n = 5), sham group; group 2 (quercetin group, n = 10) received 80 mg/kg day quercetin; group 3 (steroid group, n = 10) received steroid (mometasone furoate); and group 4 (control group, n = 10), received ovalbumin alone. Rats were sensitized by administration of ovalbumin on alternate days over 14 days via an intraperitoneal route. On day 15, in addition to ovalbumin via an intranasal route, quercetin and steroid were given over 7 days to the corresponding groups. All rats were then sacrificed and nasal turbinates were evaluated histopathologically, and serum total IgE and ovalbumin (OVA)-specific IgE values were measured before and after treatment. A significant increase in OVA-specific IgE values was detected in all groups except sham group. A significant increase was detected in post-treatment total IgE levels in the control group, while no significant change was detected in the sham, quercetin, and intranasal steroid groups. On histopathological evaluation, it was observed that findings of allergic rhinitis were suppressed in the quercetin group when compared to the control group. In immunohistochemical evaluation, it was detected that COX-2 and VIP expressions were weaker in the quercetin group compared to the control group. Based on these findings, we conclude that quercetin was effective in allergic rhinitis induced by ovalbumin in rats both histopathologically and serologically. © 2017, Springer-Verlag Berlin Heidelberg.
dc.identifier.DOI-ID10.1007/s00405-017-4602-z
dc.identifier.issn09374477
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15293
dc.language.isoEnglish
dc.publisherSpringer Verlag
dc.subjectAdministration, Intranasal
dc.subjectAnimals
dc.subjectAnti-Allergic Agents
dc.subjectAntioxidants
dc.subjectCyclooxygenase 2
dc.subjectDisease Models, Animal
dc.subjectImmunoglobulin E
dc.subjectMometasone Furoate
dc.subjectOvalbumin
dc.subjectQuercetin
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRhinitis, Allergic
dc.subjectTurbinates
dc.subjectcyclooxygenase 2
dc.subjectgelatinase B
dc.subjectimmunoglobulin E
dc.subjectmometasone furoate
dc.subjectovalbumin
dc.subjectquercetin
dc.subjectvasoactive intestinal polypeptide
dc.subjectantiallergic agent
dc.subjectantioxidant
dc.subjectcyclooxygenase 2
dc.subjectimmunoglobulin E
dc.subjectmometasone furoate
dc.subjectovalbumin
dc.subjectPtgs2 protein, rat
dc.subjectquercetin
dc.subjectallergic rhinitis
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantibody labeling
dc.subjectantigen antibody complex
dc.subjectArticle
dc.subjectblood sampling
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectinflammatory cell
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectpruritus
dc.subjectrat
dc.subjectrhinorrhea
dc.subjectserology
dc.subjectsneezing
dc.subjectsteroid therapy
dc.subjecttherapy effect
dc.subjectturbinate
dc.subjectallergic rhinitis
dc.subjectanimal
dc.subjectdisease model
dc.subjectintranasal drug administration
dc.subjectmetabolism
dc.subjectpathology
dc.subjectrandomization
dc.titleEffectiveness of quercetin in an experimental rat model of allergic rhinitis
dc.typeArticle

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