Food-induced anaphylaxis in early childhood and factors associated with its severity

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dc.contributor.authorAydogan, M
dc.contributor.authorTopal, E
dc.contributor.authorYakici, N
dc.contributor.authorAcar, HC
dc.contributor.authorDemirkale, ZH
dc.contributor.authorArga, M
dc.contributor.authorUysal, P
dc.contributor.authorAydemir, S
dc.contributor.authorSimsek, IE
dc.contributor.authorTamay, Z
dc.contributor.authorCekic, S
dc.contributor.authorCavkaytar, O
dc.contributor.authorKaplan, F
dc.contributor.authorKiykim, A
dc.contributor.authorCogurlu, MT
dc.contributor.authorSüleyman, A
dc.contributor.authorYücel, E
dc.contributor.authorAkkelle, E
dc.contributor.authorHancioglu, G
dc.contributor.authorYasar, A
dc.contributor.authorTuncel, T
dc.contributor.authorNacaroglu, HT
dc.contributor.authorAydogmus, C
dc.contributor.authorGüler, N
dc.contributor.authorCokugras, H
dc.contributor.authorSapan, N
dc.contributor.authorYüksel, H
dc.contributor.authorSancak, R
dc.contributor.authorErdogan, MS
dc.contributor.authorOzdemir, O
dc.contributor.authorOzdemir, C
dc.contributor.authorOrhan, F
dc.date.accessioned2025-04-10T10:37:23Z
dc.date.available2025-04-10T10:37:23Z
dc.description.abstractBackground: Several factors that increase the risk of severe food-induced anaphylaxis have been identified. Objective: We aimed to determine the demographic, etiologic, and clinical features of food-induced anaphylaxis in early childhood and also any other factors associated with severe anaphylaxis. Methods: We carried out a medical chart review of anaphylaxis cases from 16 pediatric allergy and immunology centers in Turkey. Results: The data of 227 patients with 266 food-induced anaphylaxis episodes were included in the study. The median (inter quartile range) age of the first anaphylaxis episode was 9 months (6-18 months); 160 of these patients were boys (70.5%). The anaphylaxis episodes were mild in 75 cases (28.2%), moderate in 154 cases (57.9%), and severe in 37 cases (13.9%). The most frequent food allergens involved were cow's milk (47.4%), nuts (16.7%), and hen's egg (15.8%). Epinephrine was administered in only 98 (36.8%) of these anaphylaxis episodes. A logistic regression analysis revealed two statistically significant factors that were independently associated with severe anaphylaxis: the presence of angioedema and hoarseness during the anaphylactic episode. Urticaria was observed less frequently in patients who developed hypotension. In addition, confusion and syncope were associated with 25.9- and 44.6-fold increases, respectively, in the risk of concomitant hypotension. Conclusion: Cow's milk, nuts, and hen's egg caused the majority of mild and moderate-to-severe anaphylaxis episodes. The presence of angioedema and hoarseness in any patient who presents with a history of food-induced anaphylaxis should alert clinicians that the reaction may be severe. In addition, the presence of confusion, syncope, or stridor probably indicates concomitant hypotension.
dc.identifier.e-issn1539-6304
dc.identifier.issn1088-5412
dc.identifier.urihttp://hdl.handle.net/20.500.14701/42990
dc.language.isoEnglish
dc.titleFood-induced anaphylaxis in early childhood and factors associated with its severity
dc.typeArticle

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