Adipocytokine levels of colon cancer patients before and after treatment

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dc.contributor.authorKosova F.
dc.contributor.authorCoskun T.
dc.contributor.authorKaya Y.
dc.contributor.authorKara E.
dc.contributor.authorAri Z.
dc.date.accessioned2024-07-22T08:18:05Z
dc.date.available2024-07-22T08:18:05Z
dc.date.issued2013
dc.description.abstractAims and background: In the present study, we investigated the associations between pre- and posttreatment levels of adiponectin, ghrelin, resistin, visfatin and leptin levels in malign and benign groups Methods and study design: 20 malign colon carcinoma groups and 20 benign groups were included in this study. Serum levels of leptin, adiponectin, resistin, ghrelin, and visfatin were measured by Elisa kits (Milipore Corporation, Billerica, MA, USA). Results: In the malign group, serum ghrelin (71.90±23.7) levels significantly decreased (p<0.05) when compared to those in the benign (88.00±16.9) group. However, serum resistin (4.92±2.2, 3.39±1.1) levels increased statistically significantly (p<0.05). In the malign group, serum visfatin (0.85±0.6, 0.83±0.5), adiponektin (60.31±23.1, 56.39±25.9) and leptin (3.08±1.4, 3.74±1.3) levels were not statistically significantly different from those in the benign group. In the malign treatment group, serum adiponectin (102.64±50.3, 66.64±27.0) levels were increased significantly (p<0.05); however, serum visfatin (1.17±0.9, 0.68±0.3), ghrelin (85.52±29.5, 82.18±18.0), leptin (5.65±2.8, 3.16±1.1), and resistin (5.96±2.8, 5.65±1.7) levels did not change significantly (p<0.05) compared to those in the respective benign treatment group. Conclusions: We showed that adipocytokines were involved in the carcinogenic process. The present results suggest that resistin and ghrelin may be important biomarkers of colon cancer. Furthermore, an in vitro study will also be necessary to evaluate the direct function of these adipocytokines in cancer cells. In addition, it will be appropriate to conduct new studies with a large number of patients at different stages.
dc.identifier.DOI-ID10.4149/BLL_2013_083
dc.identifier.issn13360345
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17175
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdipokines
dc.subjectColonic Neoplasms
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectProspective Studies
dc.subjectadipocytokine
dc.subjectarticle
dc.subjectblood
dc.subjectcolon tumor
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectprospective study
dc.titleAdipocytokine levels of colon cancer patients before and after treatment
dc.typeArticle

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