Synthesis of new 1,2,3-triazolo-nucleoside analogues with 2-propargylamino pyrimidines via click reactions
| dc.contributor.author | Ay, E | |
| dc.date.accessioned | 2025-04-10T10:29:58Z | |
| dc.date.available | 2025-04-10T10:29:58Z | |
| dc.description.abstract | In this study, it was reported that twelve nucleoside analogues were synthesized by click reactions. The reactions were carried out between the azide derivatives of D-glucopyranose, D-galactopyranose, D-ribofuranose and 2-propargylamino pyrimidine derivatives (5 and 7) that are synthesized via a different route for the first time. In the first step, N-propargyl guanidine was obtained with the reaction of 1H-pyrazole-1-carboxamidine hydrochloride and propargyl amine, then condensation of N-propargyl guanidine and beta-diketone (4 and 6) resulted in 2-propargylamino pyrimidines (5 and 7) for the first time in good yields (85%). Finally, click reactions were performed with azidosugars (8a-8f) and 2-propargylamino pyrimidine derivatives and produced twelve new nucleoside analogues in good yields. (9a-9f, 10a-10f, 65-73% yields). The chemical structures of the new derivatives were elucidated spectroscopic techniques, such as FT-IR, H-1 NMR, F-19 NMR, C-13 NMR and TOF-ESI-MS. | |
| dc.identifier.e-issn | 1532-2335 | |
| dc.identifier.issn | 1525-7770 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/36637 | |
| dc.language.iso | English | |
| dc.title | Synthesis of new 1,2,3-triazolo-nucleoside analogues with 2-propargylamino pyrimidines via click reactions | |
| dc.type | Article |