Neurotoxic effect of povidone-iodine on the rat spine using a laminectomy-durotomy model

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dc.contributor.authorAkcay E.
dc.contributor.authorErsahin Y.
dc.contributor.authorOzer F.
dc.contributor.authorDuransoy Y.K.
dc.contributor.authorCamlar M.
dc.contributor.authorAtci I.
dc.contributor.authorYagci A.
dc.contributor.authorOzer O.
dc.date.accessioned2024-07-22T08:19:16Z
dc.date.available2024-07-22T08:19:16Z
dc.date.issued2012
dc.description.abstractObjective The efficacy and safety of povidone-iodine in wound dressing and irrigation of some operative cavities were established by many in vitro and in vivo experimental reports and clinical series. However, its use in defective tissue in neural structures has not been confirmed yet. The aim of the present study was to histopathologically investigate its effect on neural tissues when applied on the upper side of defective dura. Methods Wistar rats were randomly divided into two experimental groups: control and povidone-iodine groups. In the control group, durotomy was performed following laminectomy, and the spinal cord was covered with a dry sponge. In the study group, the same procedure was performed, but open duras were covered with a sponge that had been wetted with 0.1 % povidone-iodine solution. Three weeks after surgery, all experimental animals were sacrificed, and histopathological evaluations were conducted. Results Myelin changes were absent or minimal in all cases of the control group but were present as markedly increased myelin degeneration in nearly all cases in the study group. Axonal degeneration and hypoxic neuronal damage were absent in the control group, whereas they were marked in half of the study group. No statistically significant differences were established in Schwann cell proliferation, venous congestion, and lymphocytic proliferation between the two groups. Conclusions Based on the present study, 0.1 % povidone-iodine solution cannot be recommended for wound dressing for neural structures such as myelomeningocele cases because of possible damage to underlying neural tissues. © Springer-Verlag 2012.
dc.identifier.DOI-ID10.1007/s00381-012-1885-7
dc.identifier.issn14330350
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17592
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectAnti-Infective Agents, Local
dc.subjectAxons
dc.subjectDura Mater
dc.subjectFemale
dc.subjectLaminectomy
dc.subjectMale
dc.subjectMeningomyelocele
dc.subjectMyelin Sheath
dc.subjectNerve Degeneration
dc.subjectNeurons
dc.subjectNeurotoxicity Syndromes
dc.subjectPovidone-Iodine
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSchwann Cells
dc.subjectSpinal Cord
dc.subjectSpine
dc.subjectTissue Fixation
dc.subjectVacuoles
dc.subjectmyelin
dc.subjectpovidone iodine
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcell proliferation
dc.subjectcontrolled study
dc.subjectdurotomy
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthypoxic nerve damage
dc.subjectlaminectomy
dc.subjectmale
dc.subjectmyelin deficiency
dc.subjectnerve fiber degeneration
dc.subjectnerve injury
dc.subjectnervous tissue
dc.subjectneurotoxicity
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectSchwann cell
dc.subjectspine surgery
dc.subjectsurgical sponge
dc.subjectwound dressing
dc.titleNeurotoxic effect of povidone-iodine on the rat spine using a laminectomy-durotomy model
dc.typeArticle

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